Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4151137..4151713 Replicon chromosome
Accession NZ_CP117373
Organism Salmonella enterica subsp. enterica serovar Dublin strain RM043

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag PQQ08_RS20500 Protein ID WP_001131963.1
Coordinates 4151426..4151713 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A5U1K3M6
Locus tag PQQ08_RS20495 Protein ID WP_000063141.1
Coordinates 4151137..4151439 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ08_RS20480 (4147647) 4147647..4149797 + 2151 WP_000379928.1 pyruvate/proton symporter BtsT -
PQQ08_RS20485 (4149892) 4149892..4150095 + 204 WP_000460616.1 YbdD/YjiX family protein -
PQQ08_RS20490 (4150106) 4150106..4151062 + 957 WP_000187843.1 GTPase -
PQQ08_RS20495 (4151137) 4151137..4151439 - 303 WP_000063141.1 BrnA antitoxin family protein Antitoxin
PQQ08_RS20500 (4151426) 4151426..4151713 - 288 WP_001131963.1 BrnT family toxin Toxin
PQQ08_RS20505 (4152137) 4152137..4153977 + 1841 Protein_4013 3'-5' exonuclease -
PQQ08_RS20510 (4154587) 4154587..4154919 + 333 WP_274896624.1 type I restriction endonuclease subunit M -
PQQ08_RS20515 (4154983) 4154983..4155165 + 183 WP_235005194.1 hypothetical protein -
PQQ08_RS20520 (4155595) 4155595..4156233 + 639 WP_227468645.1 N-6 DNA methylase -
PQQ08_RS20525 (4156455) 4156455..4156589 - 135 WP_001055725.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T270914 WP_001131963.1 NZ_CP117373:c4151713-4151426 [Salmonella enterica subsp. enterica serovar Dublin]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11431.99 Da        Isoelectric Point: 9.8948

>AT270914 WP_000063141.1 NZ_CP117373:c4151439-4151137 [Salmonella enterica subsp. enterica serovar Dublin]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRDKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
AlphaFold DB A0A5U1K3M6

References