Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3549823..3550443 Replicon chromosome
Accession NZ_CP117373
Organism Salmonella enterica subsp. enterica serovar Dublin strain RM043

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PQQ08_RS17720 Protein ID WP_001280991.1
Coordinates 3550225..3550443 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag PQQ08_RS17715 Protein ID WP_000344807.1
Coordinates 3549823..3550197 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ08_RS17705 (3544962) 3544962..3546155 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PQQ08_RS17710 (3546178) 3546178..3549327 + 3150 WP_052897443.1 efflux RND transporter permease AcrB -
PQQ08_RS17715 (3549823) 3549823..3550197 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
PQQ08_RS17720 (3550225) 3550225..3550443 + 219 WP_001280991.1 HHA domain-containing protein Toxin
PQQ08_RS17725 (3550622) 3550622..3551173 + 552 WP_001278787.1 maltose O-acetyltransferase -
PQQ08_RS17730 (3551291) 3551291..3551761 + 471 WP_000136183.1 YlaC family protein -
PQQ08_RS17735 (3551817) 3551817..3551957 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
PQQ08_RS17740 (3551963) 3551963..3552223 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
PQQ08_RS17745 (3552448) 3552448..3553998 + 1551 WP_000213140.1 EAL domain-containing protein -
PQQ08_RS17755 (3554229) 3554229..3554618 + 390 WP_000961287.1 MGMT family protein -
PQQ08_RS17760 (3554651) 3554651..3555220 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T270911 WP_001280991.1 NZ_CP117373:3550225-3550443 [Salmonella enterica subsp. enterica serovar Dublin]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT270911 WP_000344807.1 NZ_CP117373:3549823-3550197 [Salmonella enterica subsp. enterica serovar Dublin]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References