Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 990862..991676 | Replicon | chromosome |
| Accession | NZ_CP117373 | ||
| Organism | Salmonella enterica subsp. enterica serovar Dublin strain RM043 | ||
Toxin (Protein)
| Gene name | TacT3 | Uniprot ID | M7RPS8 |
| Locus tag | PQQ08_RS04760 | Protein ID | WP_000971649.1 |
| Coordinates | 990862..991389 (-) | Length | 176 a.a. |
Antitoxin (Protein)
| Gene name | TacA3 | Uniprot ID | M7S6I2 |
| Locus tag | PQQ08_RS04765 | Protein ID | WP_000855694.1 |
| Coordinates | 991386..991676 (-) | Length | 97 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PQQ08_RS04730 (987145) | 987145..987543 | + | 399 | Protein_926 | cytoplasmic protein | - |
| PQQ08_RS04735 (987734) | 987734..987973 | + | 240 | Protein_927 | hypothetical protein | - |
| PQQ08_RS04740 (988130) | 988130..988798 | + | 669 | WP_274896670.1 | hypothetical protein | - |
| PQQ08_RS04745 (988825) | 988825..989319 | + | 495 | WP_000424948.1 | hypothetical protein | - |
| PQQ08_RS04750 (989491) | 989491..990147 | - | 657 | WP_000420452.1 | protein-serine/threonine phosphatase | - |
| PQQ08_RS04755 (990380) | 990380..990789 | + | 410 | Protein_931 | IS5/IS1182 family transposase | - |
| PQQ08_RS04760 (990862) | 990862..991389 | - | 528 | WP_000971649.1 | GNAT family N-acetyltransferase | Toxin |
| PQQ08_RS04765 (991386) | 991386..991676 | - | 291 | WP_000855694.1 | DUF1778 domain-containing protein | Antitoxin |
| PQQ08_RS04770 (991946) | 991946..992124 | - | 179 | Protein_934 | IS3 family transposase | - |
| PQQ08_RS04775 (992528) | 992528..992971 | - | 444 | WP_000715096.1 | SPI-1 type III secretion system invasion lipoprotein InvH | - |
| PQQ08_RS04780 (993427) | 993427..994077 | + | 651 | WP_001674874.1 | type III secretion system transcriptional activator InvF | - |
| PQQ08_RS04785 (994074) | 994074..995762 | + | 1689 | WP_000848113.1 | type III secretion system outer membrane ring protein InvG | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 990649..990789 | 140 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 176 a.a. Molecular weight: 19026.88 Da Isoelectric Point: 9.3905
>T270906 WP_000971649.1 NZ_CP117373:c991389-990862 [Salmonella enterica subsp. enterica serovar Dublin]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHALQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHALQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL
Download Length: 528 bp
Antitoxin
Download Length: 97 a.a. Molecular weight: 10664.50 Da Isoelectric Point: 6.3133
>AT270906 WP_000855694.1 NZ_CP117373:c991676-991386 [Salmonella enterica subsp. enterica serovar Dublin]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK
Download Length: 291 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3V5VVF5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3V8SJE7 |