Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4175660..4176176 Replicon chromosome
Accession NZ_CP117371
Organism Salmonella enterica subsp. enterica serovar Newport strain RM049

Toxin (Protein)


Gene name relE Uniprot ID A0A0R9NWE9
Locus tag PQQ06_RS20415 Protein ID WP_000220579.1
Coordinates 4175660..4175944 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag PQQ06_RS20420 Protein ID WP_000212724.1
Coordinates 4175934..4176176 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ06_RS20400 (4170776) 4170776..4172428 + 1653 WP_000155055.1 alpha,alpha-phosphotrehalase -
PQQ06_RS20405 (4172837) 4172837..4174975 + 2139 WP_000187821.1 anaerobic ribonucleoside-triphosphate reductase -
PQQ06_RS20410 (4175192) 4175192..4175656 + 465 WP_001009175.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
PQQ06_RS20415 (4175660) 4175660..4175944 - 285 WP_000220579.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PQQ06_RS20420 (4175934) 4175934..4176176 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PQQ06_RS20425 (4176254) 4176254..4178167 - 1914 WP_274898466.1 BglG family transcription antiterminator -
PQQ06_RS20430 (4178184) 4178184..4178924 - 741 WP_000779247.1 KDGP aldolase family protein -
PQQ06_RS20435 (4178921) 4178921..4180039 - 1119 WP_001139182.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
PQQ06_RS20440 (4180023) 4180023..4181156 - 1134 WP_274898467.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10884.70 Da        Isoelectric Point: 10.0482

>T270896 WP_000220579.1 NZ_CP117371:c4175944-4175660 [Salmonella enterica subsp. enterica serovar Newport]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDTNKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT270896 WP_000212724.1 NZ_CP117371:c4176176-4175934 [Salmonella enterica subsp. enterica serovar Newport]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NWE9

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References