Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3485865..3486485 Replicon chromosome
Accession NZ_CP117371
Organism Salmonella enterica subsp. enterica serovar Newport strain RM049

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PQQ06_RS17245 Protein ID WP_001280991.1
Coordinates 3486267..3486485 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag PQQ06_RS17240 Protein ID WP_000344807.1
Coordinates 3485865..3486239 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ06_RS17230 (3481004) 3481004..3482197 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PQQ06_RS17235 (3482220) 3482220..3485369 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
PQQ06_RS17240 (3485865) 3485865..3486239 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
PQQ06_RS17245 (3486267) 3486267..3486485 + 219 WP_001280991.1 HHA domain-containing protein Toxin
PQQ06_RS17250 (3486664) 3486664..3487215 + 552 WP_001278792.1 maltose O-acetyltransferase -
PQQ06_RS17255 (3487332) 3487332..3487802 + 471 WP_000136181.1 YlaC family protein -
PQQ06_RS17260 (3487858) 3487858..3487998 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
PQQ06_RS17265 (3488004) 3488004..3488264 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
PQQ06_RS17270 (3488489) 3488489..3490039 + 1551 WP_274898436.1 EAL domain-containing protein -
PQQ06_RS17280 (3490270) 3490270..3490659 + 390 WP_000961287.1 MGMT family protein -
PQQ06_RS17285 (3490692) 3490692..3491261 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T270893 WP_001280991.1 NZ_CP117371:3486267-3486485 [Salmonella enterica subsp. enterica serovar Newport]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT270893 WP_000344807.1 NZ_CP117371:3485865-3486239 [Salmonella enterica subsp. enterica serovar Newport]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References