Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 990993..991807 | Replicon | chromosome |
| Accession | NZ_CP117371 | ||
| Organism | Salmonella enterica subsp. enterica serovar Newport strain RM049 | ||
Toxin (Protein)
| Gene name | TacT3 | Uniprot ID | Q57KM2 |
| Locus tag | PQQ06_RS04715 | Protein ID | WP_000971655.1 |
| Coordinates | 990993..991520 (-) | Length | 176 a.a. |
Antitoxin (Protein)
| Gene name | TacA3 | Uniprot ID | M7S6I2 |
| Locus tag | PQQ06_RS04720 | Protein ID | WP_000855694.1 |
| Coordinates | 991517..991807 (-) | Length | 97 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PQQ06_RS04685 (987275) | 987275..987673 | + | 399 | Protein_917 | cytoplasmic protein | - |
| PQQ06_RS04690 (987864) | 987864..988103 | + | 240 | Protein_918 | hypothetical protein | - |
| PQQ06_RS04695 (988260) | 988260..988928 | + | 669 | WP_274898527.1 | hypothetical protein | - |
| PQQ06_RS04700 (988955) | 988955..989449 | + | 495 | WP_000424948.1 | hypothetical protein | - |
| PQQ06_RS04705 (989621) | 989621..990277 | - | 657 | WP_000420452.1 | protein-serine/threonine phosphatase | - |
| PQQ06_RS04710 (990510) | 990510..990920 | + | 411 | Protein_922 | transposase | - |
| PQQ06_RS04715 (990993) | 990993..991520 | - | 528 | WP_000971655.1 | GNAT family N-acetyltransferase | Toxin |
| PQQ06_RS04720 (991517) | 991517..991807 | - | 291 | WP_000855694.1 | DUF1778 domain-containing protein | Antitoxin |
| PQQ06_RS04725 (992077) | 992077..992255 | - | 179 | Protein_925 | IS3 family transposase | - |
| PQQ06_RS04730 (992496) | 992496..992822 | + | 327 | WP_274898529.1 | hypothetical protein | - |
| PQQ06_RS04735 (993095) | 993095..993442 | - | 348 | WP_001669174.1 | DUF1493 family protein | - |
| PQQ06_RS04740 (993427) | 993427..993876 | - | 450 | WP_000381610.1 | membrane protein | - |
| PQQ06_RS04745 (994308) | 994308..994751 | - | 444 | WP_000715099.1 | SPI-1 type III secretion system invasion lipoprotein InvH | - |
| PQQ06_RS04750 (995207) | 995207..995857 | + | 651 | WP_001674874.1 | type III secretion system transcriptional activator InvF | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 990696..990920 | 224 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 176 a.a. Molecular weight: 19069.91 Da Isoelectric Point: 9.6420
>T270888 WP_000971655.1 NZ_CP117371:c991520-990993 [Salmonella enterica subsp. enterica serovar Newport]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL
Download Length: 528 bp
Antitoxin
Download Length: 97 a.a. Molecular weight: 10664.50 Da Isoelectric Point: 6.3133
>AT270888 WP_000855694.1 NZ_CP117371:c991807-991517 [Salmonella enterica subsp. enterica serovar Newport]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK
Download Length: 291 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| PDB | 6G96 | |
| PDB | 7AK9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3V8SJE7 |