Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4440838..4441619 Replicon chromosome
Accession NZ_CP117370
Organism Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain RM054

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag PQP97_RS21840 Protein ID WP_000626099.1
Coordinates 4440838..4441329 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag PQP97_RS21845 Protein ID WP_001110452.1
Coordinates 4441326..4441619 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP97_RS21800 (4436024) 4436024..4436266 - 243 WP_197603740.1 hypothetical protein -
PQP97_RS21805 (4436263) 4436263..4436619 - 357 WP_033567083.1 hypothetical protein -
PQP97_RS21810 (4436616) 4436616..4437488 - 873 WP_033567082.1 ParA family protein -
PQP97_RS21815 (4437679) 4437679..4437756 - 78 Protein_4267 helix-turn-helix domain-containing protein -
PQP97_RS21820 (4437847) 4437847..4438179 - 333 WP_001165471.1 MerR family transcriptional regulator -
PQP97_RS21825 (4438251) 4438251..4438628 + 378 WP_000916345.1 EthD family reductase -
PQP97_RS21830 (4439661) 4439661..4439735 + 75 Protein_4270 porin family protein -
PQP97_RS21835 (4439838) 4439838..4440590 + 753 WP_000842434.1 non-specific acid phosphatase -
PQP97_RS21840 (4440838) 4440838..4441329 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
PQP97_RS21845 (4441326) 4441326..4441619 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
PQP97_RS21850 (4441936) 4441936..4442157 + 222 WP_001576552.1 hypothetical protein -
PQP97_RS21855 (4442422) 4442422..4443297 + 876 WP_000921674.1 AraC family transcriptional regulator -
PQP97_RS21860 (4443294) 4443294..4443581 + 288 WP_001269916.1 transcriptional regulator RtsB -
PQP97_RS21865 (4443604) 4443604..4443819 + 216 WP_001595136.1 hypothetical protein -
PQP97_RS21870 (4443827) 4443827..4444096 + 270 WP_010989096.1 hypothetical protein -
PQP97_RS21875 (4444390) 4444390..4445295 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T270883 WP_000626099.1 NZ_CP117370:c4441329-4440838 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT270883 WP_001110452.1 NZ_CP117370:c4441619-4441326 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References