270881

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4136504..4137080 Replicon chromosome
Accession NZ_CP117370
Organism Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain RM054

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag PQP97_RS20335 Protein ID WP_001131963.1
Coordinates 4136793..4137080 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag PQP97_RS20330 Protein ID WP_000063142.1
Coordinates 4136504..4136806 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP97_RS20315 (4133014) 4133014..4135164 + 2151 WP_000379927.1 pyruvate/proton symporter BtsT -
PQP97_RS20320 (4135259) 4135259..4135462 + 204 WP_000460616.1 YbdD/YjiX family protein -
PQP97_RS20325 (4135473) 4135473..4136429 + 957 WP_000187839.1 GTPase -
PQP97_RS20330 (4136504) 4136504..4136806 - 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
PQP97_RS20335 (4136793) 4136793..4137080 - 288 WP_001131963.1 BrnT family toxin Toxin
PQP97_RS20340 (4137349) 4137349..4138263 - 915 WP_000290512.1 restriction endonuclease -
PQP97_RS20345 (4138461) 4138461..4141970 + 3510 WP_001043484.1 type I restriction-modification system endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T270881 WP_001131963.1 NZ_CP117370:c4137080-4136793 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT270881 WP_000063142.1 NZ_CP117370:c4136806-4136504 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
AlphaFold DB A0A4D6PB01

References