Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3517595..3518215 Replicon chromosome
Accession NZ_CP117370
Organism Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain RM054

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PQP97_RS17455 Protein ID WP_001280991.1
Coordinates 3517997..3518215 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag PQP97_RS17450 Protein ID WP_000344807.1
Coordinates 3517595..3517969 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP97_RS17440 (3512734) 3512734..3513927 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PQP97_RS17445 (3513950) 3513950..3517099 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
PQP97_RS17450 (3517595) 3517595..3517969 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
PQP97_RS17455 (3517997) 3517997..3518215 + 219 WP_001280991.1 HHA domain-containing protein Toxin
PQP97_RS17460 (3518394) 3518394..3518945 + 552 WP_001278792.1 maltose O-acetyltransferase -
PQP97_RS17465 (3519062) 3519062..3519532 + 471 WP_000136181.1 YlaC family protein -
PQP97_RS17470 (3519588) 3519588..3519728 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
PQP97_RS17475 (3519734) 3519734..3519994 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
PQP97_RS17480 (3520219) 3520219..3521769 + 1551 WP_000213139.1 EAL domain-containing protein -
PQP97_RS17490 (3522000) 3522000..3522389 + 390 WP_000961285.1 MGMT family protein -
PQP97_RS17495 (3522422) 3522422..3522991 - 570 WP_000779803.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T270878 WP_001280991.1 NZ_CP117370:3517997-3518215 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT270878 WP_000344807.1 NZ_CP117370:3517595-3517969 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References