Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4462801..4463582 Replicon chromosome
Accession NZ_CP117367
Organism Salmonella enterica subsp. enterica serovar Dublin strain RM079

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A0R9NZI3
Locus tag PQQ12_RS22025 Protein ID WP_000625912.1
Coordinates 4462801..4463292 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID M7RNV8
Locus tag PQQ12_RS22030 Protein ID WP_001110450.1
Coordinates 4463289..4463582 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ12_RS21990 (4458261) 4458261..4458608 + 348 WP_000887832.1 divalent cation tolerance protein CutA -
PQQ12_RS21995 (4458584) 4458584..4460287 + 1704 WP_000068885.1 protein-disulfide reductase DsbD -
PQQ12_RS22000 (4460324) 4460324..4460899 + 576 WP_001188509.1 transcriptional regulator -
PQQ12_RS22010 (4461170) 4461170..4461244 - 75 Protein_4311 helix-turn-helix domain-containing protein -
PQQ12_RS22015 (4461624) 4461624..4461701 + 78 Protein_4312 porin family protein -
PQQ12_RS22020 (4461801) 4461801..4462553 + 753 WP_000842432.1 non-specific acid phosphatase -
PQQ12_RS22025 (4462801) 4462801..4463292 - 492 WP_000625912.1 GNAT family N-acetyltransferase Toxin
PQQ12_RS22030 (4463289) 4463289..4463582 - 294 WP_001110450.1 DUF1778 domain-containing protein Antitoxin
PQQ12_RS22035 (4463899) 4463899..4464121 + 223 Protein_4316 hypothetical protein -
PQQ12_RS22040 (4464385) 4464385..4465260 + 876 WP_000921679.1 AraC family transcriptional regulator -
PQQ12_RS22045 (4465257) 4465257..4465544 + 288 WP_001269916.1 transcriptional regulator RtsB -
PQQ12_RS22050 (4465567) 4465567..4465782 + 216 WP_001595136.1 hypothetical protein -
PQQ12_RS22055 (4465790) 4465790..4466059 + 270 WP_077906657.1 hypothetical protein -
PQQ12_RS22060 (4466353) 4466353..4467258 - 906 WP_001268195.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17606.43 Da        Isoelectric Point: 7.7297

>T270860 WP_000625912.1 NZ_CP117367:c4463292-4462801 [Salmonella enterica subsp. enterica serovar Dublin]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSSVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10949.56 Da        Isoelectric Point: 8.6141

>AT270860 WP_001110450.1 NZ_CP117367:c4463582-4463289 [Salmonella enterica subsp. enterica serovar Dublin]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NZI3

Antitoxin

Source ID Structure
AlphaFold DB A0A0R9PGG6

References