Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4264451..4265027 Replicon chromosome
Accession NZ_CP117367
Organism Salmonella enterica subsp. enterica serovar Dublin strain RM079

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag PQQ12_RS21010 Protein ID WP_001131963.1
Coordinates 4264740..4265027 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A5U1K3M6
Locus tag PQQ12_RS21005 Protein ID WP_000063141.1
Coordinates 4264451..4264753 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ12_RS20990 (4260961) 4260961..4263111 + 2151 WP_000379928.1 pyruvate/proton symporter BtsT -
PQQ12_RS20995 (4263206) 4263206..4263409 + 204 WP_000460616.1 YbdD/YjiX family protein -
PQQ12_RS21000 (4263420) 4263420..4264376 + 957 WP_000187843.1 GTPase -
PQQ12_RS21005 (4264451) 4264451..4264753 - 303 WP_000063141.1 BrnA antitoxin family protein Antitoxin
PQQ12_RS21010 (4264740) 4264740..4265027 - 288 WP_001131963.1 BrnT family toxin Toxin
PQQ12_RS21015 (4265451) 4265451..4267292 + 1842 WP_000974635.1 nuclease-related domain-containing DEAD/DEAH box helicase -
PQQ12_RS21020 (4267905) 4267905..4268480 + 576 WP_000593782.1 restriction endonuclease subunit S -
PQQ12_RS21025 (4268485) 4268485..4269549 + 1065 WP_223151228.1 N-6 DNA methylase -
PQQ12_RS21030 (4269771) 4269771..4269905 - 135 WP_001055725.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T270857 WP_001131963.1 NZ_CP117367:c4265027-4264740 [Salmonella enterica subsp. enterica serovar Dublin]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11431.99 Da        Isoelectric Point: 9.8948

>AT270857 WP_000063141.1 NZ_CP117367:c4264753-4264451 [Salmonella enterica subsp. enterica serovar Dublin]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRDKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
AlphaFold DB A0A5U1K3M6

References