Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 198174..198934 Replicon chromosome
Accession NZ_CP117367
Organism Salmonella enterica subsp. enterica serovar Dublin strain RM079

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag PQQ12_RS00935 Protein ID WP_000533909.1
Coordinates 198449..198934 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag PQQ12_RS00930 Protein ID WP_000965886.1
Coordinates 198174..198461 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ12_RS00910 (193579) 193579..194490 + 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
PQQ12_RS00915 (194500) 194500..196569 + 2070 WP_001291741.1 glycine--tRNA ligase subunit beta -
PQQ12_RS00920 (196959) 196959..197312 + 354 Protein_182 IS3 family transposase -
PQQ12_RS00925 (197529) 197529..197996 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
PQQ12_RS00930 (198174) 198174..198461 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
PQQ12_RS00935 (198449) 198449..198934 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
PQQ12_RS00940 (199305) 199305..199844 - 540 WP_000047147.1 copper-binding periplasmic metallochaperone CueP -
PQQ12_RS00945 (200018) 200018..200230 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
PQQ12_RS00950 (200518) 200518..200808 - 291 WP_000455790.1 HTH-type transcriptional regulator -
PQQ12_RS00955 (201247) 201247..201957 + 711 WP_000190524.1 DUF3053 domain-containing protein -
PQQ12_RS00960 (202007) 202007..202981 - 975 WP_000804678.1 glyoxylate/hydroxypyruvate reductase GhrB -
PQQ12_RS00965 (203200) 203200..203862 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T270843 WP_000533909.1 NZ_CP117367:198449-198934 [Salmonella enterica subsp. enterica serovar Dublin]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT270843 WP_000965886.1 NZ_CP117367:198174-198461 [Salmonella enterica subsp. enterica serovar Dublin]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References