Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4257515..4258296 Replicon chromosome
Accession NZ_CP117365
Organism Salmonella enterica subsp. enterica serovar Newport strain RM089

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A0R9NZI3
Locus tag PQP78_RS20820 Protein ID WP_000625912.1
Coordinates 4257515..4258006 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID M7RNV8
Locus tag PQP78_RS20825 Protein ID WP_001110450.1
Coordinates 4258003..4258296 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP78_RS20790 (4253776) 4253776..4254273 - 498 WP_001670425.1 FimD/PapC N-terminal domain-containing protein -
PQP78_RS20795 (4254397) 4254397..4255227 - 831 WP_001180236.1 fimbria/pilus periplasmic chaperone -
PQP78_RS20800 (4255429) 4255429..4255734 - 306 WP_000370555.1 PapB/FocB family fimbrial expression transcriptional regulator -
PQP78_RS20805 (4256265) 4256265..4256408 + 144 Protein_4066 transposase -
PQP78_RS20810 (4256425) 4256425..4256771 + 347 Protein_4067 Rpn family recombination-promoting nuclease/putative transposase -
PQP78_RS20815 (4257052) 4257052..4257300 - 249 Protein_4068 IS481 family transposase -
PQP78_RS20820 (4257515) 4257515..4258006 - 492 WP_000625912.1 GNAT family N-acetyltransferase Toxin
PQP78_RS20825 (4258003) 4258003..4258296 - 294 WP_001110450.1 DUF1778 domain-containing protein Antitoxin
PQP78_RS20830 (4258613) 4258613..4258835 + 223 Protein_4071 hypothetical protein -
PQP78_RS20835 (4259097) 4259097..4259972 + 876 WP_000921676.1 AraC family transcriptional regulator -
PQP78_RS20840 (4259969) 4259969..4260256 + 288 WP_001269916.1 transcriptional regulator RtsB -
PQP78_RS20845 (4260249) 4260249..4260431 - 183 WP_001670702.1 ATP-binding cassette domain-containing protein -
PQP78_RS20850 (4260451) 4260451..4260550 + 100 Protein_4075 hypothetical protein -
PQP78_RS20855 (4260661) 4260661..4260795 + 135 Protein_4076 hypothetical protein -
PQP78_RS20860 (4261089) 4261089..4262079 - 991 Protein_4077 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4250604..4262034 11430


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17606.43 Da        Isoelectric Point: 7.7297

>T270840 WP_000625912.1 NZ_CP117365:c4258006-4257515 [Salmonella enterica subsp. enterica serovar Newport]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSSVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10949.56 Da        Isoelectric Point: 8.6141

>AT270840 WP_001110450.1 NZ_CP117365:c4258296-4258003 [Salmonella enterica subsp. enterica serovar Newport]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NZI3

Antitoxin

Source ID Structure
AlphaFold DB A0A0R9PGG6

References