Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3450550..3451170 Replicon chromosome
Accession NZ_CP117365
Organism Salmonella enterica subsp. enterica serovar Newport strain RM089

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PQP78_RS17005 Protein ID WP_001280991.1
Coordinates 3450952..3451170 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag PQP78_RS17000 Protein ID WP_000344807.1
Coordinates 3450550..3450924 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP78_RS16990 (3445689) 3445689..3446882 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PQP78_RS16995 (3446905) 3446905..3450054 + 3150 WP_274891827.1 efflux RND transporter permease AcrB -
PQP78_RS17000 (3450550) 3450550..3450924 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
PQP78_RS17005 (3450952) 3450952..3451170 + 219 WP_001280991.1 HHA domain-containing protein Toxin
PQP78_RS17010 (3451349) 3451349..3451900 + 552 WP_001278792.1 maltose O-acetyltransferase -
PQP78_RS17015 (3452017) 3452017..3452487 + 471 WP_000136181.1 YlaC family protein -
PQP78_RS17020 (3452543) 3452543..3452683 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
PQP78_RS17025 (3452689) 3452689..3452949 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
PQP78_RS17030 (3453174) 3453174..3454724 + 1551 WP_000213138.1 EAL domain-containing protein -
PQP78_RS17040 (3454955) 3454955..3455344 + 390 WP_000961287.1 MGMT family protein -
PQP78_RS17045 (3455377) 3455377..3455946 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T270836 WP_001280991.1 NZ_CP117365:3450952-3451170 [Salmonella enterica subsp. enterica serovar Newport]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT270836 WP_000344807.1 NZ_CP117365:3450550-3450924 [Salmonella enterica subsp. enterica serovar Newport]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References