Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4236908..4237424 Replicon chromosome
Accession NZ_CP117362
Organism Salmonella enterica subsp. enterica serovar Dublin strain RM092

Toxin (Protein)


Gene name relE Uniprot ID M7RIY5
Locus tag PQQ00_RS20885 Protein ID WP_000220574.1
Coordinates 4236908..4237192 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag PQQ00_RS20890 Protein ID WP_000212724.1
Coordinates 4237182..4237424 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ00_RS20870 (4232024) 4232024..4233676 + 1653 WP_001751520.1 alpha,alpha-phosphotrehalase -
PQQ00_RS20875 (4234085) 4234085..4236223 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
PQQ00_RS20880 (4236440) 4236440..4236904 + 465 WP_001009173.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
PQQ00_RS20885 (4236908) 4236908..4237192 - 285 WP_000220574.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PQQ00_RS20890 (4237182) 4237182..4237424 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PQQ00_RS20895 (4237502) 4237502..4239415 - 1914 WP_001212138.1 PRD domain-containing protein -
PQQ00_RS20900 (4239432) 4239432..4240172 - 741 WP_000779259.1 KDGP aldolase family protein -
PQQ00_RS20905 (4240169) 4240169..4241287 - 1119 WP_001139169.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
PQQ00_RS20910 (4241271) 4241271..4242404 - 1134 WP_000459958.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10869.68 Da        Isoelectric Point: 9.8739

>T270820 WP_000220574.1 NZ_CP117362:c4237192-4236908 [Salmonella enterica subsp. enterica serovar Dublin]
MTYELEFDPRALKEWHKLGDTVKAQIKKKLADVLLDPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT270820 WP_000212724.1 NZ_CP117362:c4237424-4237182 [Salmonella enterica subsp. enterica serovar Dublin]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M7RIY5

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References