Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4145484..4146060 Replicon chromosome
Accession NZ_CP117362
Organism Salmonella enterica subsp. enterica serovar Dublin strain RM092

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag PQQ00_RS20445 Protein ID WP_001131963.1
Coordinates 4145773..4146060 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A5U1K3M6
Locus tag PQQ00_RS20440 Protein ID WP_000063141.1
Coordinates 4145484..4145786 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ00_RS20425 (4141994) 4141994..4144144 + 2151 WP_000379928.1 pyruvate/proton symporter BtsT -
PQQ00_RS20430 (4144239) 4144239..4144442 + 204 WP_000460616.1 YbdD/YjiX family protein -
PQQ00_RS20435 (4144453) 4144453..4145409 + 957 WP_000187843.1 GTPase -
PQQ00_RS20440 (4145484) 4145484..4145786 - 303 WP_000063141.1 BrnA antitoxin family protein Antitoxin
PQQ00_RS20445 (4145773) 4145773..4146060 - 288 WP_001131963.1 BrnT family toxin Toxin
PQQ00_RS20450 (4146498) 4146498..4148339 + 1842 WP_000974635.1 nuclease-related domain-containing DEAD/DEAH box helicase -
PQQ00_RS20455 (4148952) 4148952..4149527 + 576 WP_000593782.1 restriction endonuclease subunit S -
PQQ00_RS20460 (4149532) 4149532..4150596 + 1065 WP_223151228.1 N-6 DNA methylase -
PQQ00_RS20465 (4150818) 4150818..4150952 - 135 WP_001055725.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T270818 WP_001131963.1 NZ_CP117362:c4146060-4145773 [Salmonella enterica subsp. enterica serovar Dublin]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11431.99 Da        Isoelectric Point: 9.8948

>AT270818 WP_000063141.1 NZ_CP117362:c4145786-4145484 [Salmonella enterica subsp. enterica serovar Dublin]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRDKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
AlphaFold DB A0A5U1K3M6

References