Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 824281..824941 Replicon chromosome
Accession NZ_CP117362
Organism Salmonella enterica subsp. enterica serovar Dublin strain RM092

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag PQQ00_RS03975 Protein ID WP_000244756.1
Coordinates 824528..824941 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag PQQ00_RS03970 Protein ID WP_000351186.1
Coordinates 824281..824547 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ00_RS03950 (820212) 820212..821645 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
PQQ00_RS03955 (821800) 821800..822114 + 315 WP_001182980.1 N(4)-acetylcytidine aminohydrolase -
PQQ00_RS03960 (822276) 822276..822935 + 660 WP_000250289.1 hemolysin III family protein -
PQQ00_RS03965 (823051) 823051..824031 - 981 WP_000874174.1 tRNA-modifying protein YgfZ -
PQQ00_RS03970 (824281) 824281..824547 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
PQQ00_RS03975 (824528) 824528..824941 + 414 WP_000244756.1 protein YgfX Toxin
PQQ00_RS03980 (824994) 824994..825515 - 522 WP_001055885.1 flavodoxin FldB -
PQQ00_RS03985 (825628) 825628..826524 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
PQQ00_RS03990 (826548) 826548..827261 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PQQ00_RS03995 (827267) 827267..829000 + 1734 WP_000813387.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T270808 WP_000244756.1 NZ_CP117362:824528-824941 [Salmonella enterica subsp. enterica serovar Dublin]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT270808 WP_000351186.1 NZ_CP117362:824281-824547 [Salmonella enterica subsp. enterica serovar Dublin]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References