Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4343603..4344384 Replicon chromosome
Accession NZ_CP117359
Organism Salmonella enterica subsp. enterica serovar Dublin strain RM094

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A0R9NZI3
Locus tag PQP87_RS21465 Protein ID WP_000625912.1
Coordinates 4343603..4344094 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID M7RNV8
Locus tag PQP87_RS21470 Protein ID WP_001110450.1
Coordinates 4344091..4344384 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP87_RS21430 (4339063) 4339063..4339410 + 348 WP_000887832.1 divalent cation tolerance protein CutA -
PQP87_RS21435 (4339386) 4339386..4341089 + 1704 WP_000068885.1 protein-disulfide reductase DsbD -
PQP87_RS21440 (4341126) 4341126..4341701 + 576 WP_001188509.1 transcriptional regulator -
PQP87_RS21450 (4341972) 4341972..4342046 - 75 Protein_4196 helix-turn-helix domain-containing protein -
PQP87_RS21455 (4342426) 4342426..4342503 + 78 Protein_4197 porin family protein -
PQP87_RS21460 (4342603) 4342603..4343355 + 753 WP_000842432.1 non-specific acid phosphatase -
PQP87_RS21465 (4343603) 4343603..4344094 - 492 WP_000625912.1 GNAT family N-acetyltransferase Toxin
PQP87_RS21470 (4344091) 4344091..4344384 - 294 WP_001110450.1 DUF1778 domain-containing protein Antitoxin
PQP87_RS21475 (4344701) 4344701..4344923 + 223 Protein_4201 hypothetical protein -
PQP87_RS21480 (4345187) 4345187..4346062 + 876 WP_000921679.1 AraC family transcriptional regulator -
PQP87_RS21485 (4346059) 4346059..4346346 + 288 WP_001269916.1 transcriptional regulator RtsB -
PQP87_RS21490 (4346369) 4346369..4346584 + 216 WP_001595136.1 hypothetical protein -
PQP87_RS21495 (4346592) 4346592..4346861 + 270 WP_077906657.1 hypothetical protein -
PQP87_RS21500 (4347155) 4347155..4348060 - 906 WP_001268195.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17606.43 Da        Isoelectric Point: 7.7297

>T270798 WP_000625912.1 NZ_CP117359:c4344094-4343603 [Salmonella enterica subsp. enterica serovar Dublin]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSSVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10949.56 Da        Isoelectric Point: 8.6141

>AT270798 WP_001110450.1 NZ_CP117359:c4344384-4344091 [Salmonella enterica subsp. enterica serovar Dublin]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NZI3

Antitoxin

Source ID Structure
AlphaFold DB A0A0R9PGG6

References