Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4236663..4237179 Replicon chromosome
Accession NZ_CP117359
Organism Salmonella enterica subsp. enterica serovar Dublin strain RM094

Toxin (Protein)


Gene name relE Uniprot ID M7RIY5
Locus tag PQP87_RS20890 Protein ID WP_000220574.1
Coordinates 4236663..4236947 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag PQP87_RS20895 Protein ID WP_000212724.1
Coordinates 4236937..4237179 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP87_RS20875 (4231779) 4231779..4233431 + 1653 WP_001751520.1 alpha,alpha-phosphotrehalase -
PQP87_RS20880 (4233840) 4233840..4235978 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
PQP87_RS20885 (4236195) 4236195..4236659 + 465 WP_001009173.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
PQP87_RS20890 (4236663) 4236663..4236947 - 285 WP_000220574.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PQP87_RS20895 (4236937) 4236937..4237179 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PQP87_RS20900 (4237257) 4237257..4239170 - 1914 WP_001212138.1 PRD domain-containing protein -
PQP87_RS20905 (4239187) 4239187..4239927 - 741 WP_000779259.1 KDGP aldolase family protein -
PQP87_RS20910 (4239924) 4239924..4241042 - 1119 WP_001139169.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
PQP87_RS20915 (4241026) 4241026..4242159 - 1134 WP_000459958.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10869.68 Da        Isoelectric Point: 9.8739

>T270797 WP_000220574.1 NZ_CP117359:c4236947-4236663 [Salmonella enterica subsp. enterica serovar Dublin]
MTYELEFDPRALKEWHKLGDTVKAQIKKKLADVLLDPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT270797 WP_000212724.1 NZ_CP117359:c4237179-4236937 [Salmonella enterica subsp. enterica serovar Dublin]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M7RIY5

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References