Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4145254..4145830 Replicon chromosome
Accession NZ_CP117359
Organism Salmonella enterica subsp. enterica serovar Dublin strain RM094

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag PQP87_RS20450 Protein ID WP_001131963.1
Coordinates 4145543..4145830 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A5U1K3M6
Locus tag PQP87_RS20445 Protein ID WP_000063141.1
Coordinates 4145254..4145556 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP87_RS20430 (4141764) 4141764..4143914 + 2151 WP_000379928.1 pyruvate/proton symporter BtsT -
PQP87_RS20435 (4144009) 4144009..4144212 + 204 WP_000460616.1 YbdD/YjiX family protein -
PQP87_RS20440 (4144223) 4144223..4145179 + 957 WP_000187843.1 GTPase -
PQP87_RS20445 (4145254) 4145254..4145556 - 303 WP_000063141.1 BrnA antitoxin family protein Antitoxin
PQP87_RS20450 (4145543) 4145543..4145830 - 288 WP_001131963.1 BrnT family toxin Toxin
PQP87_RS20455 (4146254) 4146254..4148095 + 1842 WP_000974635.1 nuclease-related domain-containing DEAD/DEAH box helicase -
PQP87_RS20460 (4148708) 4148708..4149283 + 576 WP_000593782.1 restriction endonuclease subunit S -
PQP87_RS20465 (4149288) 4149288..4150352 + 1065 WP_223151228.1 N-6 DNA methylase -
PQP87_RS20470 (4150574) 4150574..4150708 - 135 WP_001055725.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T270795 WP_001131963.1 NZ_CP117359:c4145830-4145543 [Salmonella enterica subsp. enterica serovar Dublin]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11431.99 Da        Isoelectric Point: 9.8948

>AT270795 WP_000063141.1 NZ_CP117359:c4145556-4145254 [Salmonella enterica subsp. enterica serovar Dublin]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRDKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
AlphaFold DB A0A5U1K3M6

References