Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 987103..987917 Replicon chromosome
Accession NZ_CP117359
Organism Salmonella enterica subsp. enterica serovar Dublin strain RM094

Toxin (Protein)


Gene name TacT3 Uniprot ID M7RPS8
Locus tag PQP87_RS04735 Protein ID WP_000971649.1
Coordinates 987103..987630 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag PQP87_RS04740 Protein ID WP_000855694.1
Coordinates 987627..987917 (-) Length 97 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP87_RS04705 (983386) 983386..983784 + 399 Protein_921 cytoplasmic protein -
PQP87_RS04710 (983975) 983975..984214 + 240 Protein_922 hypothetical protein -
PQP87_RS04715 (984371) 984371..985039 + 669 WP_000445914.1 hypothetical protein -
PQP87_RS04720 (985066) 985066..985560 + 495 WP_000424948.1 hypothetical protein -
PQP87_RS04725 (985732) 985732..986388 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
PQP87_RS04730 (986621) 986621..987030 + 410 Protein_926 IS5/IS1182 family transposase -
PQP87_RS04735 (987103) 987103..987630 - 528 WP_000971649.1 GNAT family N-acetyltransferase Toxin
PQP87_RS04740 (987627) 987627..987917 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
PQP87_RS04745 (988187) 988187..988365 - 179 Protein_929 IS3 family transposase -
PQP87_RS04750 (988769) 988769..989212 - 444 WP_000715096.1 SPI-1 type III secretion system invasion lipoprotein InvH -
PQP87_RS04755 (989668) 989668..990318 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
PQP87_RS04760 (990315) 990315..992003 + 1689 WP_000848113.1 type III secretion system outer membrane ring protein InvG -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 986890..987030 140


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(1-95)


Sequences


Toxin        


Download         Length: 176 a.a.        Molecular weight: 19026.88 Da        Isoelectric Point: 9.3905

>T270787 WP_000971649.1 NZ_CP117359:c987630-987103 [Salmonella enterica subsp. enterica serovar Dublin]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHALQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp


Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT270787 WP_000855694.1 NZ_CP117359:c987917-987627 [Salmonella enterica subsp. enterica serovar Dublin]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A3V5VVF5


Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References