270778

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4345806..4346587 Replicon chromosome
Accession NZ_CP117357
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain RM096

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag PQQ15_RS21260 Protein ID WP_000626099.1
Coordinates 4345806..4346297 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag PQQ15_RS21265 Protein ID WP_001110452.1
Coordinates 4346294..4346587 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ15_RS21225 (4341801) 4341801..4342376 + 576 WP_001188509.1 transcriptional regulator -
PQQ15_RS21235 (4342647) 4342647..4342724 - 78 Protein_4151 helix-turn-helix domain-containing protein -
PQQ15_RS21240 (4342815) 4342815..4343147 - 333 WP_001165471.1 MerR family transcriptional regulator -
PQQ15_RS21245 (4343219) 4343219..4343596 + 378 WP_000916345.1 EthD family reductase -
PQQ15_RS21250 (4344629) 4344629..4344703 + 75 Protein_4154 porin family protein -
PQQ15_RS21255 (4344806) 4344806..4345558 + 753 WP_000842434.1 non-specific acid phosphatase -
PQQ15_RS21260 (4345806) 4345806..4346297 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
PQQ15_RS21265 (4346294) 4346294..4346587 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
PQQ15_RS21270 (4346904) 4346904..4347125 + 222 WP_001576552.1 hypothetical protein -
PQQ15_RS21275 (4347390) 4347390..4348265 + 876 WP_000921674.1 AraC family transcriptional regulator -
PQQ15_RS21280 (4348262) 4348262..4348549 + 288 WP_001269916.1 transcriptional regulator RtsB -
PQQ15_RS21285 (4348572) 4348572..4348787 + 216 WP_001595136.1 hypothetical protein -
PQQ15_RS21290 (4348795) 4348795..4349064 + 270 WP_010989096.1 hypothetical protein -
PQQ15_RS21295 (4349358) 4349358..4350263 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T270778 WP_000626099.1 NZ_CP117357:c4346297-4345806 [Salmonella enterica subsp. enterica serovar Typhimurium]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT270778 WP_001110452.1 NZ_CP117357:c4346587-4346294 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
AlphaFold DB A0A5I1DGA4

References