Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4217180..4217696 Replicon chromosome
Accession NZ_CP117357
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain RM096

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag PQQ15_RS20595 Protein ID WP_000220578.1
Coordinates 4217180..4217464 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag PQQ15_RS20600 Protein ID WP_000212724.1
Coordinates 4217454..4217696 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ15_RS20580 (4212392) 4212392..4214044 + 1653 WP_000155057.1 alpha,alpha-phosphotrehalase -
PQQ15_RS20585 (4214453) 4214453..4216591 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
PQQ15_RS20590 (4216712) 4216712..4217176 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
PQQ15_RS20595 (4217180) 4217180..4217464 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PQQ15_RS20600 (4217454) 4217454..4217696 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PQQ15_RS20605 (4217774) 4217774..4219687 - 1914 WP_001212137.1 BglG family transcription antiterminator -
PQQ15_RS20610 (4219704) 4219704..4220444 - 741 WP_000779263.1 KDGP aldolase family protein -
PQQ15_RS20615 (4220441) 4220441..4221559 - 1119 WP_001139187.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
PQQ15_RS20620 (4221543) 4221543..4222676 - 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T270777 WP_000220578.1 NZ_CP117357:c4217464-4217180 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT270777 WP_000212724.1 NZ_CP117357:c4217696-4217454 [Salmonella enterica subsp. enterica serovar Typhimurium]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References