Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3523335..3523955 Replicon chromosome
Accession NZ_CP117357
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain RM096

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PQQ15_RS17440 Protein ID WP_001280991.1
Coordinates 3523737..3523955 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag PQQ15_RS17435 Protein ID WP_000344807.1
Coordinates 3523335..3523709 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ15_RS17425 (3518475) 3518475..3519668 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PQQ15_RS17430 (3519691) 3519691..3522839 + 3149 Protein_3407 efflux RND transporter permease AcrB -
PQQ15_RS17435 (3523335) 3523335..3523709 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
PQQ15_RS17440 (3523737) 3523737..3523955 + 219 WP_001280991.1 HHA domain-containing protein Toxin
PQQ15_RS17445 (3524134) 3524134..3524685 + 552 WP_001278792.1 maltose O-acetyltransferase -
PQQ15_RS17450 (3524802) 3524802..3525272 + 471 WP_000136181.1 YlaC family protein -
PQQ15_RS17455 (3525328) 3525328..3525468 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
PQQ15_RS17460 (3525474) 3525474..3525734 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
PQQ15_RS17465 (3525959) 3525959..3527509 + 1551 WP_000213139.1 EAL domain-containing protein -
PQQ15_RS17475 (3527740) 3527740..3528129 + 390 WP_000961285.1 MGMT family protein -
PQQ15_RS17480 (3528162) 3528162..3528731 - 570 WP_000779803.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T270773 WP_001280991.1 NZ_CP117357:3523737-3523955 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT270773 WP_000344807.1 NZ_CP117357:3523335-3523709 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References