Detailed information of TA system TA027077

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sezT-pezT/zeta-couple_hipB
• Location: 1556707..1557953
• Replicon: chromosome
• Accession: NC_017582
• Organism: Streptococcus equi subsp. zooepidemicus ATCC 35246

Toxin (Protein)

• Gene name: sezT
• Uniprot ID: A0A6D2LV21
• Locus tag: SESEC_RS07340
• Protein ID: WP_014623239.1
• Coordinates: 1556707..1557477 (-)
• Length: 257 a.a.

Antitoxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: SESEC_RS07345
• Protein ID: WP_014623240.1
• Coordinates: 1557477..1557953 (-)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SESEC_RS10685	1551783..1551974	-	192	WP_014623235.1	hypothetical protein	-
SESEC_RS07325	1552104..1554749	-	2646	WP_014623236.1	AAA family ATPase	-
SESEC_RS07330	1554754..1555440	-	687	WP_014623237.1	hypothetical protein	-
SESEC_RS07335	1555433..1556704	-	1272	WP_038674121.1	hypothetical protein	-
SESEC_RS07340	1556707..1557477	-	771	WP_014623239.1	zeta toxin family protein	Toxin
SESEC_RS07345	1557477..1557953	-	477	WP_014623240.1	helix-turn-helix domain-containing protein	Antitoxin
SESEC_RS07350	1557970..1558311	-	342	WP_049780516.1	hypothetical protein	-
SESEC_RS07355	1558356..1558751	-	396	WP_014623241.1	hypothetical protein	-
SESEC_RS07360	1558755..1558982	-	228	WP_000110926.1	hypothetical protein	-
SESEC_RS07365	1559036..1560122	-	1087	Protein_1425	toprim domain-containing protein	-
SESEC_RS07370	1560161..1560799	-	639	WP_014623243.1	hypothetical protein	-
SESEC_RS07375	1560982..1562496	-	1515	WP_038674112.1	ABC transporter ATP-binding protein/permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1545841..1604269	58428

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (26-215)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 257 a.a.
• Molecular weight: 29112.91 Da
• Isoelectric Point: 5.8794

>T27077 WP_014623239.1 NC_017582:c1557477-1556707 [Streptococcus equi subsp. zooepidemicus ATCC 35246]
MRLEEFSQDDFDLALKRTIRSLTRGKTTSVSPKAILLGGQSGAGKTTIHRIEQKEFQGNIIIIDGDSYRSLHPNYLALHE
EYGKDSVDYTKGFAGKMVEHLVDELSKQGYHLLIEGTLRTTEVPRKTARLLNSRGYQVSLALIATKPELSYLSTLIRYEE
VYAVNPNQARATPKEHHDGIVDHLVDNLRELENDKLFGQIQIYQRDRTCVYDSKTDEGSAADVLQECLFGKWSKVEEEML
KVGQECLRELEFKGEC

Nucleotide

• Length: 771 bp

>T27077 NC_017582:c1557477-1556707 [Streptococcus equi subsp. zooepidemicus ATCC 35246]
ATGCGGTTAGAAGAATTTAGTCAAGATGACTTTGACCTAGCCTTAAAACGAACCATTCGTTCTTTAACTCGTGGTAAAAC
AACATCAGTTAGTCCAAAGGCAATTTTACTTGGTGGACAAAGCGGAGCAGGAAAAACAACGATACACCGTATCGAGCAAA
AAGAGTTTCAAGGGAATATCATTATTATTGACGGCGATAGCTATCGTTCTTTACACCCGAATTATCTAGCTTTACACGAA
GAATACGGTAAGGATAGCGTGGATTATACCAAAGGTTTTGCAGGAAAAATGGTGGAACATCTTGTCGATGAGCTAAGTAA
ACAAGGTTATCATTTGTTAATTGAAGGAACCTTGAGAACGACAGAAGTCCCACGAAAAACAGCTCGGTTATTGAATTCGA
GAGGTTATCAAGTCTCTTTAGCTTTGATAGCGACCAAGCCTGAATTGTCATATCTCAGTACCTTAATACGCTATGAGGAA
GTCTATGCGGTGAACCCAAACCAGGCTAGAGCAACTCCTAAAGAACATCACGATGGTATTGTAGACCATTTAGTCGATAA
TCTAAGAGAGTTAGAAAACGATAAACTCTTTGGCCAGATTCAAATATATCAAAGAGATAGAACCTGTGTCTATGATTCAA
AGACGGATGAAGGTTCAGCAGCCGATGTCCTACAAGAATGCCTCTTCGGAAAATGGAGTAAGGTCGAGGAAGAGATGTTG
AAGGTGGGACAAGAATGTTTGAGGGAGTTAGAGTTTAAAGGAGAGTGCTGA

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18032.39 Da
• Isoelectric Point: 4.3193

>AT27077 WP_014623240.1 NC_017582:c1557953-1557477 [Streptococcus equi subsp. zooepidemicus ATCC 35246]
MIGDNIKSLRKTHDLTQPEFAKIVGISRNSLSRYENGTSSVSTELIDRICQKFNVSYVDIVGEEKLLTPVEDYQLTLKVE
VIKERGAAILSELYCYQDSQGIAFDDETSPWILMSDDLSDLINTKIYLVNTFDEVERYNGYLDGIERMLELARHQVVA

Nucleotide

• Length: 477 bp

>AT27077 NC_017582:c1557953-1557477 [Streptococcus equi subsp. zooepidemicus ATCC 35246]
ATGATTGGAGACAATATCAAATCGTTACGTAAAACCCATGATTTAACACAACCAGAATTCGCAAAGATTGTGGGAATTTC
ACGAAATAGCCTTAGTCGTTATGAAAATGGAACCAGCTCTGTTTCAACAGAACTGATAGATCGTATTTGTCAGAAATTCA
ACGTGTCTTATGTCGACATTGTAGGAGAAGAAAAGCTGTTAACACCAGTAGAAGATTATCAATTGACGCTGAAAGTCGAA
GTCATCAAAGAACGTGGTGCAGCGATTTTATCCGAACTGTATTGCTATCAAGATAGTCAAGGAATTGCTTTTGATGATGA
GACTAGCCCTTGGATTTTGATGAGTGATGACTTGTCAGACCTTATCAACACTAAGATTTACCTTGTCAATACCTTTGACG
AAGTAGAGCGCTACAATGGTTATTTGGATGGCATTGAGCGTATGTTGGAGCTTGCTCGACATCAGGTGGTGGCTTAA

Structures

Toxin

• AlphaFold DB: A0A6D2LV21