Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 868204..868864 Replicon chromosome
Accession NZ_CP117357
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain RM096

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag PQQ15_RS04265 Protein ID WP_000244756.1
Coordinates 868451..868864 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag PQQ15_RS04260 Protein ID WP_000351186.1
Coordinates 868204..868470 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ15_RS04240 (864132) 864132..865565 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
PQQ15_RS04245 (865724) 865724..866035 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
PQQ15_RS04250 (866199) 866199..866858 + 660 WP_000250289.1 hemolysin III family protein -
PQQ15_RS04255 (866974) 866974..867954 - 981 WP_000874172.1 tRNA-modifying protein YgfZ -
PQQ15_RS04260 (868204) 868204..868470 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
PQQ15_RS04265 (868451) 868451..868864 + 414 WP_000244756.1 protein YgfX Toxin
PQQ15_RS04270 (868917) 868917..869438 - 522 WP_001055885.1 flavodoxin FldB -
PQQ15_RS04275 (869551) 869551..870447 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
PQQ15_RS04280 (870471) 870471..871184 + 714 WP_000745625.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PQQ15_RS04285 (871190) 871190..872922 + 1733 Protein_840 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T270765 WP_000244756.1 NZ_CP117357:868451-868864 [Salmonella enterica subsp. enterica serovar Typhimurium]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT270765 WP_000351186.1 NZ_CP117357:868204-868470 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References