Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4343090..4343871 Replicon chromosome
Accession NZ_CP117354
Organism Salmonella enterica subsp. enterica serovar Dublin strain RM099

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A0R9NZI3
Locus tag PQP84_RS21455 Protein ID WP_000625912.1
Coordinates 4343090..4343581 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID M7RNV8
Locus tag PQP84_RS21460 Protein ID WP_001110450.1
Coordinates 4343578..4343871 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP84_RS21420 (4338550) 4338550..4338897 + 348 WP_000887832.1 divalent cation tolerance protein CutA -
PQP84_RS21425 (4338873) 4338873..4340576 + 1704 WP_000068885.1 protein-disulfide reductase DsbD -
PQP84_RS21430 (4340613) 4340613..4341188 + 576 WP_001188509.1 transcriptional regulator -
PQP84_RS21440 (4341459) 4341459..4341533 - 75 Protein_4195 helix-turn-helix domain-containing protein -
PQP84_RS21445 (4341913) 4341913..4341990 + 78 Protein_4196 porin family protein -
PQP84_RS21450 (4342090) 4342090..4342842 + 753 WP_000842432.1 non-specific acid phosphatase -
PQP84_RS21455 (4343090) 4343090..4343581 - 492 WP_000625912.1 GNAT family N-acetyltransferase Toxin
PQP84_RS21460 (4343578) 4343578..4343871 - 294 WP_001110450.1 DUF1778 domain-containing protein Antitoxin
PQP84_RS21465 (4344188) 4344188..4344410 + 223 Protein_4200 hypothetical protein -
PQP84_RS21470 (4344674) 4344674..4345549 + 876 WP_000921679.1 AraC family transcriptional regulator -
PQP84_RS21475 (4345546) 4345546..4345833 + 288 WP_001269916.1 transcriptional regulator RtsB -
PQP84_RS21480 (4345856) 4345856..4346071 + 216 WP_001595136.1 hypothetical protein -
PQP84_RS21485 (4346079) 4346079..4346348 + 270 WP_077906657.1 hypothetical protein -
PQP84_RS21490 (4346642) 4346642..4347547 - 906 WP_001268195.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17606.43 Da        Isoelectric Point: 7.7297

>T270755 WP_000625912.1 NZ_CP117354:c4343581-4343090 [Salmonella enterica subsp. enterica serovar Dublin]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSSVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10949.56 Da        Isoelectric Point: 8.6141

>AT270755 WP_001110450.1 NZ_CP117354:c4343871-4343578 [Salmonella enterica subsp. enterica serovar Dublin]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NZI3

Antitoxin

Source ID Structure
AlphaFold DB A0A0R9PGG6

References