Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4236156..4236672 Replicon chromosome
Accession NZ_CP117354
Organism Salmonella enterica subsp. enterica serovar Dublin strain RM099

Toxin (Protein)


Gene name relE Uniprot ID M7RIY5
Locus tag PQP84_RS20880 Protein ID WP_000220574.1
Coordinates 4236156..4236440 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag PQP84_RS20885 Protein ID WP_000212724.1
Coordinates 4236430..4236672 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP84_RS20865 (4231272) 4231272..4232924 + 1653 WP_001751520.1 alpha,alpha-phosphotrehalase -
PQP84_RS20870 (4233333) 4233333..4235471 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
PQP84_RS20875 (4235688) 4235688..4236152 + 465 WP_001009173.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
PQP84_RS20880 (4236156) 4236156..4236440 - 285 WP_000220574.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PQP84_RS20885 (4236430) 4236430..4236672 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PQP84_RS20890 (4236750) 4236750..4238663 - 1914 WP_001212138.1 PRD domain-containing protein -
PQP84_RS20895 (4238680) 4238680..4239420 - 741 WP_000779259.1 KDGP aldolase family protein -
PQP84_RS20900 (4239417) 4239417..4240535 - 1119 WP_001139169.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
PQP84_RS20905 (4240519) 4240519..4241651 - 1133 Protein_4092 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10869.68 Da        Isoelectric Point: 9.8739

>T270754 WP_000220574.1 NZ_CP117354:c4236440-4236156 [Salmonella enterica subsp. enterica serovar Dublin]
MTYELEFDPRALKEWHKLGDTVKAQIKKKLADVLLDPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT270754 WP_000212724.1 NZ_CP117354:c4236672-4236430 [Salmonella enterica subsp. enterica serovar Dublin]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M7RIY5

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References