Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4144735..4145311 Replicon chromosome
Accession NZ_CP117354
Organism Salmonella enterica subsp. enterica serovar Dublin strain RM099

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag PQP84_RS20440 Protein ID WP_001131963.1
Coordinates 4145024..4145311 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A5U1K3M6
Locus tag PQP84_RS20435 Protein ID WP_000063141.1
Coordinates 4144735..4145037 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP84_RS20420 (4141245) 4141245..4143395 + 2151 WP_000379928.1 pyruvate/proton symporter BtsT -
PQP84_RS20425 (4143490) 4143490..4143693 + 204 WP_000460616.1 YbdD/YjiX family protein -
PQP84_RS20430 (4143704) 4143704..4144660 + 957 WP_000187843.1 GTPase -
PQP84_RS20435 (4144735) 4144735..4145037 - 303 WP_000063141.1 BrnA antitoxin family protein Antitoxin
PQP84_RS20440 (4145024) 4145024..4145311 - 288 WP_001131963.1 BrnT family toxin Toxin
PQP84_RS20445 (4145749) 4145749..4147590 + 1842 WP_000974635.1 nuclease-related domain-containing DEAD/DEAH box helicase -
PQP84_RS20450 (4148203) 4148203..4148778 + 576 WP_000593782.1 restriction endonuclease subunit S -
PQP84_RS20455 (4149208) 4149208..4149846 + 639 WP_227468645.1 N-6 DNA methylase -
PQP84_RS20460 (4150068) 4150068..4150202 - 135 WP_001055725.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T270752 WP_001131963.1 NZ_CP117354:c4145311-4145024 [Salmonella enterica subsp. enterica serovar Dublin]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11431.99 Da        Isoelectric Point: 9.8948

>AT270752 WP_000063141.1 NZ_CP117354:c4145037-4144735 [Salmonella enterica subsp. enterica serovar Dublin]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRDKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
AlphaFold DB A0A5U1K3M6

References