Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 824100..824760 Replicon chromosome
Accession NZ_CP117354
Organism Salmonella enterica subsp. enterica serovar Dublin strain RM099

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag PQP84_RS03975 Protein ID WP_000244756.1
Coordinates 824347..824760 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag PQP84_RS03970 Protein ID WP_000351186.1
Coordinates 824100..824366 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP84_RS03950 (820031) 820031..821464 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
PQP84_RS03955 (821619) 821619..821933 + 315 WP_001182980.1 N(4)-acetylcytidine aminohydrolase -
PQP84_RS03960 (822095) 822095..822754 + 660 WP_000250289.1 hemolysin III family protein -
PQP84_RS03965 (822870) 822870..823850 - 981 WP_000874174.1 tRNA-modifying protein YgfZ -
PQP84_RS03970 (824100) 824100..824366 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
PQP84_RS03975 (824347) 824347..824760 + 414 WP_000244756.1 protein YgfX Toxin
PQP84_RS03980 (824813) 824813..825334 - 522 WP_001055885.1 flavodoxin FldB -
PQP84_RS03985 (825447) 825447..826343 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
PQP84_RS03990 (826367) 826367..827080 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PQP84_RS03995 (827086) 827086..828819 + 1734 WP_000813387.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T270742 WP_000244756.1 NZ_CP117354:824347-824760 [Salmonella enterica subsp. enterica serovar Dublin]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT270742 WP_000351186.1 NZ_CP117354:824100-824366 [Salmonella enterica subsp. enterica serovar Dublin]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References