Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4338183..4338964 Replicon chromosome
Accession NZ_CP117351
Organism Salmonella enterica subsp. enterica serovar Dublin strain RM100

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A0R9NZI3
Locus tag PQQ10_RS21450 Protein ID WP_000625912.1
Coordinates 4338183..4338674 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID M7RNV8
Locus tag PQQ10_RS21455 Protein ID WP_001110450.1
Coordinates 4338671..4338964 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ10_RS21415 (4333643) 4333643..4333990 + 348 WP_000887832.1 divalent cation tolerance protein CutA -
PQQ10_RS21420 (4333966) 4333966..4335669 + 1704 WP_000068885.1 protein-disulfide reductase DsbD -
PQQ10_RS21425 (4335706) 4335706..4336281 + 576 WP_001188509.1 transcriptional regulator -
PQQ10_RS21435 (4336552) 4336552..4336626 - 75 Protein_4195 helix-turn-helix domain-containing protein -
PQQ10_RS21440 (4337006) 4337006..4337083 + 78 Protein_4196 porin family protein -
PQQ10_RS21445 (4337183) 4337183..4337935 + 753 WP_000842432.1 non-specific acid phosphatase -
PQQ10_RS21450 (4338183) 4338183..4338674 - 492 WP_000625912.1 GNAT family N-acetyltransferase Toxin
PQQ10_RS21455 (4338671) 4338671..4338964 - 294 WP_001110450.1 DUF1778 domain-containing protein Antitoxin
PQQ10_RS21460 (4339281) 4339281..4339503 + 223 Protein_4200 hypothetical protein -
PQQ10_RS21465 (4339767) 4339767..4340642 + 876 WP_000921679.1 AraC family transcriptional regulator -
PQQ10_RS21470 (4340639) 4340639..4340926 + 288 WP_001269916.1 transcriptional regulator RtsB -
PQQ10_RS21475 (4340949) 4340949..4341164 + 216 WP_001595136.1 hypothetical protein -
PQQ10_RS21480 (4341172) 4341172..4341441 + 270 WP_077906657.1 hypothetical protein -
PQQ10_RS21485 (4341735) 4341735..4342640 - 906 WP_001268195.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17606.43 Da        Isoelectric Point: 7.7297

>T270732 WP_000625912.1 NZ_CP117351:c4338674-4338183 [Salmonella enterica subsp. enterica serovar Dublin]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSSVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10949.56 Da        Isoelectric Point: 8.6141

>AT270732 WP_001110450.1 NZ_CP117351:c4338964-4338671 [Salmonella enterica subsp. enterica serovar Dublin]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NZI3

Antitoxin

Source ID Structure
AlphaFold DB A0A0R9PGG6

References