Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4231244..4231760 Replicon chromosome
Accession NZ_CP117351
Organism Salmonella enterica subsp. enterica serovar Dublin strain RM100

Toxin (Protein)


Gene name relE Uniprot ID M7RIY5
Locus tag PQQ10_RS20875 Protein ID WP_000220574.1
Coordinates 4231244..4231528 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag PQQ10_RS20880 Protein ID WP_000212724.1
Coordinates 4231518..4231760 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ10_RS20860 (4226360) 4226360..4228012 + 1653 WP_001751520.1 alpha,alpha-phosphotrehalase -
PQQ10_RS20865 (4228421) 4228421..4230559 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
PQQ10_RS20870 (4230776) 4230776..4231240 + 465 WP_001009173.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
PQQ10_RS20875 (4231244) 4231244..4231528 - 285 WP_000220574.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PQQ10_RS20880 (4231518) 4231518..4231760 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PQQ10_RS20885 (4231838) 4231838..4233751 - 1914 WP_001212138.1 PRD domain-containing protein -
PQQ10_RS20890 (4233768) 4233768..4234508 - 741 WP_000779259.1 KDGP aldolase family protein -
PQQ10_RS20895 (4234505) 4234505..4235623 - 1119 WP_001139169.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
PQQ10_RS20900 (4235607) 4235607..4236740 - 1134 WP_000459958.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10869.68 Da        Isoelectric Point: 9.8739

>T270731 WP_000220574.1 NZ_CP117351:c4231528-4231244 [Salmonella enterica subsp. enterica serovar Dublin]
MTYELEFDPRALKEWHKLGDTVKAQIKKKLADVLLDPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT270731 WP_000212724.1 NZ_CP117351:c4231760-4231518 [Salmonella enterica subsp. enterica serovar Dublin]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M7RIY5

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References