Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4139842..4140418 Replicon chromosome
Accession NZ_CP117351
Organism Salmonella enterica subsp. enterica serovar Dublin strain RM100

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag PQQ10_RS20435 Protein ID WP_001131963.1
Coordinates 4140131..4140418 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A5U1K3M6
Locus tag PQQ10_RS20430 Protein ID WP_000063141.1
Coordinates 4139842..4140144 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ10_RS20415 (4136352) 4136352..4138502 + 2151 WP_000379928.1 pyruvate/proton symporter BtsT -
PQQ10_RS20420 (4138597) 4138597..4138800 + 204 WP_000460616.1 YbdD/YjiX family protein -
PQQ10_RS20425 (4138811) 4138811..4139767 + 957 WP_000187843.1 GTPase -
PQQ10_RS20430 (4139842) 4139842..4140144 - 303 WP_000063141.1 BrnA antitoxin family protein Antitoxin
PQQ10_RS20435 (4140131) 4140131..4140418 - 288 WP_001131963.1 BrnT family toxin Toxin
PQQ10_RS20440 (4140841) 4140841..4142682 + 1842 WP_000974635.1 nuclease-related domain-containing DEAD/DEAH box helicase -
PQQ10_RS20445 (4143295) 4143295..4143870 + 576 WP_000593782.1 restriction endonuclease subunit S -
PQQ10_RS20450 (4143957) 4143957..4145126 + 1170 WP_241431418.1 N-6 DNA methylase -
PQQ10_RS20455 (4145158) 4145158..4145292 - 135 WP_001055725.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T270729 WP_001131963.1 NZ_CP117351:c4140418-4140131 [Salmonella enterica subsp. enterica serovar Dublin]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11431.99 Da        Isoelectric Point: 9.8948

>AT270729 WP_000063141.1 NZ_CP117351:c4140144-4139842 [Salmonella enterica subsp. enterica serovar Dublin]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRDKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
AlphaFold DB A0A5U1K3M6

References