Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3539872..3540492 Replicon chromosome
Accession NZ_CP117351
Organism Salmonella enterica subsp. enterica serovar Dublin strain RM100

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PQQ10_RS17665 Protein ID WP_001280991.1
Coordinates 3540274..3540492 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag PQQ10_RS17660 Protein ID WP_000344807.1
Coordinates 3539872..3540246 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ10_RS17650 (3535012) 3535012..3536205 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PQQ10_RS17655 (3536228) 3536228..3539376 + 3149 Protein_3456 efflux RND transporter permease AcrB -
PQQ10_RS17660 (3539872) 3539872..3540246 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
PQQ10_RS17665 (3540274) 3540274..3540492 + 219 WP_001280991.1 HHA domain-containing protein Toxin
PQQ10_RS17670 (3540671) 3540671..3541222 + 552 WP_001278787.1 maltose O-acetyltransferase -
PQQ10_RS17675 (3541340) 3541340..3541810 + 471 WP_000136183.1 YlaC family protein -
PQQ10_RS17680 (3541866) 3541866..3542006 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
PQQ10_RS17685 (3542012) 3542012..3542272 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
PQQ10_RS17690 (3542497) 3542497..3544047 + 1551 WP_000213140.1 EAL domain-containing protein -
PQQ10_RS17700 (3544278) 3544278..3544667 + 390 WP_000961287.1 MGMT family protein -
PQQ10_RS17705 (3544700) 3544700..3545269 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T270726 WP_001280991.1 NZ_CP117351:3540274-3540492 [Salmonella enterica subsp. enterica serovar Dublin]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT270726 WP_000344807.1 NZ_CP117351:3539872-3540246 [Salmonella enterica subsp. enterica serovar Dublin]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References