Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3455980..3456600 Replicon chromosome
Accession NZ_CP117348
Organism Salmonella enterica subsp. enterica serovar Heidelberg strain RM101

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PQQ11_RS16995 Protein ID WP_001280991.1
Coordinates 3456382..3456600 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag PQQ11_RS16990 Protein ID WP_000344807.1
Coordinates 3455980..3456354 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ11_RS16980 (3451120) 3451120..3452313 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PQQ11_RS16985 (3452336) 3452336..3455484 + 3149 Protein_3319 efflux RND transporter permease AcrB -
PQQ11_RS16990 (3455980) 3455980..3456354 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
PQQ11_RS16995 (3456382) 3456382..3456600 + 219 WP_001280991.1 HHA domain-containing protein Toxin
PQQ11_RS17000 (3456779) 3456779..3457330 + 552 WP_001278792.1 maltose O-acetyltransferase -
PQQ11_RS17005 (3457447) 3457447..3457917 + 471 WP_000136181.1 YlaC family protein -
PQQ11_RS17010 (3457973) 3457973..3458113 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
PQQ11_RS17015 (3458119) 3458119..3458379 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
PQQ11_RS17020 (3458604) 3458604..3460154 + 1551 WP_000213139.1 EAL domain-containing protein -
PQQ11_RS17030 (3460385) 3460385..3460774 + 390 WP_000961285.1 MGMT family protein -
PQQ11_RS17035 (3460807) 3460807..3461376 - 570 WP_000779803.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T270704 WP_001280991.1 NZ_CP117348:3456382-3456600 [Salmonella enterica subsp. enterica serovar Heidelberg]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT270704 WP_000344807.1 NZ_CP117348:3455980-3456354 [Salmonella enterica subsp. enterica serovar Heidelberg]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References