270703

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2402946..2403468 Replicon chromosome
Accession NZ_CP117348
Organism Salmonella enterica subsp. enterica serovar Heidelberg strain RM101

Toxin (Protein)


Gene name stbE Uniprot ID A0A5V5H0Y9
Locus tag PQQ11_RS11675 Protein ID WP_000221348.1
Coordinates 2403184..2403468 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag PQQ11_RS11670 Protein ID WP_000885424.1
Coordinates 2402946..2403194 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ11_RS11645 (2398655) 2398655..2399563 - 909 WP_274897865.1 LysR family transcriptional regulator -
PQQ11_RS11650 (2400429) 2400429..2401143 + 715 Protein_2278 helix-turn-helix domain-containing protein -
PQQ11_RS11655 (2401199) 2401199..2402106 - 908 Protein_2279 hypothetical protein -
PQQ11_RS11660 (2402257) 2402257..2402589 - 333 WP_000253097.1 DUF1493 family protein -
PQQ11_RS11665 (2402579) 2402579..2402794 - 216 WP_000206207.1 hypothetical protein -
PQQ11_RS11670 (2402946) 2402946..2403194 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PQQ11_RS11675 (2403184) 2403184..2403468 + 285 WP_000221348.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PQQ11_RS11680 (2403639) 2403639..2404028 + 390 WP_001531585.1 RidA family protein -
PQQ11_RS11685 (2404086) 2404086..2405159 - 1074 WP_000954686.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
PQQ11_RS11690 (2405352) 2405352..2405840 - 489 WP_001293629.1 MarR family winged helix-turn-helix transcriptional regulator -
PQQ11_RS11695 (2405885) 2405885..2407393 + 1509 WP_000214838.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2396509..2410250 13741


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11093.88 Da        Isoelectric Point: 10.6500

>T270703 WP_000221348.1 NZ_CP117348:2403184-2403468 [Salmonella enterica subsp. enterica serovar Heidelberg]
MTYKLAFNESALKEWKKMGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT270703 WP_000885424.1 NZ_CP117348:2402946-2403194 [Salmonella enterica subsp. enterica serovar Heidelberg]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5V5H0Y9

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References