Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 847807..848467 Replicon chromosome
Accession NZ_CP117348
Organism Salmonella enterica subsp. enterica serovar Heidelberg strain RM101

Toxin (Protein)


Gene name cptA Uniprot ID A0A5V1QI13
Locus tag PQQ11_RS04130 Protein ID WP_000244754.1
Coordinates 848054..848467 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag PQQ11_RS04125 Protein ID WP_000351186.1
Coordinates 847807..848073 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ11_RS04105 (843735) 843735..845168 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
PQQ11_RS04110 (845327) 845327..845638 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
PQQ11_RS04115 (845802) 845802..846461 + 660 WP_000250288.1 hemolysin III family protein -
PQQ11_RS04120 (846577) 846577..847557 - 981 WP_000874176.1 tRNA-modifying protein YgfZ -
PQQ11_RS04125 (847807) 847807..848073 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
PQQ11_RS04130 (848054) 848054..848467 + 414 WP_000244754.1 protein YgfX Toxin
PQQ11_RS04135 (848520) 848520..849041 - 522 WP_001055885.1 flavodoxin FldB -
PQQ11_RS04140 (849154) 849154..850050 + 897 WP_000434301.1 site-specific tyrosine recombinase XerD -
PQQ11_RS04145 (850074) 850074..850787 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PQQ11_RS04150 (850793) 850793..852526 + 1734 WP_274898091.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16197.18 Da        Isoelectric Point: 10.7537

>T270697 WP_000244754.1 NZ_CP117348:848054-848467 [Salmonella enterica subsp. enterica serovar Heidelberg]
VVLWQSDLRVSWRAQWISLLIHGLIAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT270697 WP_000351186.1 NZ_CP117348:847807-848073 [Salmonella enterica subsp. enterica serovar Heidelberg]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5V1QI13

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References