Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 225539..226299 Replicon chromosome
Accession NZ_CP117348
Organism Salmonella enterica subsp. enterica serovar Heidelberg strain RM101

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag PQQ11_RS01095 Protein ID WP_000533909.1
Coordinates 225814..226299 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag PQQ11_RS01090 Protein ID WP_000965886.1
Coordinates 225539..225826 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ11_RS01065 (220834) 220834..221136 + 303 WP_000605590.1 YsaB family lipoprotein -
PQQ11_RS01070 (221275) 221275..222186 + 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
PQQ11_RS01075 (222196) 222196..224265 + 2070 WP_001291736.1 glycine--tRNA ligase subunit beta -
PQQ11_RS01080 (224447) 224447..224722 + 276 Protein_214 IS3 family transposase -
PQQ11_RS01085 (224894) 224894..225361 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
PQQ11_RS01090 (225539) 225539..225826 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
PQQ11_RS01095 (225814) 225814..226299 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
PQQ11_RS01100 (226671) 226671..227210 - 540 WP_000047149.1 copper-binding periplasmic metallochaperone CueP -
PQQ11_RS01105 (227384) 227384..227596 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
PQQ11_RS01110 (227885) 227885..228175 - 291 WP_000455790.1 HTH-type transcriptional regulator -
PQQ11_RS01115 (228613) 228613..229323 + 711 WP_000190524.1 DUF3053 domain-containing protein -
PQQ11_RS01120 (229373) 229373..230347 - 975 WP_274898058.1 glyoxylate/hydroxypyruvate reductase GhrB -
PQQ11_RS01125 (230566) 230566..231228 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T270695 WP_000533909.1 NZ_CP117348:225814-226299 [Salmonella enterica subsp. enterica serovar Heidelberg]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT270695 WP_000965886.1 NZ_CP117348:225539-225826 [Salmonella enterica subsp. enterica serovar Heidelberg]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References