Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 111188..111843 Replicon plasmid pRM104_1
Accession NZ_CP117347
Organism Salmonella enterica subsp. enterica serovar Dublin strain RM104

Toxin (Protein)


Gene name vagD Uniprot ID M7RF18
Locus tag PQP85_RS24450 Protein ID WP_000812999.1
Coordinates 111188..111616 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID H9AC95
Locus tag PQP85_RS24455 Protein ID WP_001261283.1
Coordinates 111613..111843 (-) Length 77 a.a.

Genomic Context

PQP85_RS24415PQP85_RS24420PQP85_RS24425PQP85_RS24430PQP85_RS24435PQP85_RS24440PQP85_RS24445PQP85_RS24460PQP85_RS24465PQP85_RS24470PQP85_RS24475PQP85_RS24480PQP85_RS24485PQP85_RS24490PQP85_RS24495PQP85_RS24500PQP85_RS24450PQP85_RS24455
Location: 106589..107353 (765 bp)
Type: Others
Protein ID: WP_000827659.1
Location: 107340..107615 (276 bp)
Type: Others
Protein ID: WP_001020576.1
Location: 107615..108328 (714 bp)
Type: Others
Protein ID: WP_000801115.1
Location: 108453..109037 (585 bp)
Type: Others
Protein ID: WP_001575501.1
Location: 109110..109322 (213 bp)
Type: Others
Protein ID: WP_000063794.1
Location: 109583..109744 (162 bp)
Type: Others
Protein ID: WP_001816720.1
Location: 109770..110618 (849 bp)
Type: Others
Protein ID: WP_000175391.1
Location: 112588..112806 (219 bp)
Type: Others
Protein ID: WP_000813641.1
Location: 112808..113113 (306 bp)
Type: Others
Protein ID: WP_001159863.1
Location: 113115..113405 (291 bp)
Type: Others
Protein ID: WP_001266176.1
Location: 113402..113923 (522 bp)
Type: Others
Protein ID: WP_000198608.1
Location: 113958..114740 (783 bp)
Type: Others
Protein ID: WP_000082169.1
Location: 114749..115432 (684 bp)
Type: Others
Protein ID: WP_001751692.1
Location: 115486..115974 (489 bp)
Type: Others
Protein ID: WP_001075507.1
Location: 115968..116304 (337 bp)
Type: Others
Protein ID: Protein_148
Location: 116295..116636 (342 bp)
Type: Others
Protein ID: Protein_149
Location: 111188..111616 (429 bp)
Type: Toxin
Protein ID: WP_000812999.1
Location: 111613..111843 (231 bp)
Type: Antitoxin
Protein ID: WP_001261283.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
PQP85_RS24415 (PQP85_24415)106589..107353+765WP_000827659.1K88 minor fimbrial subunit faeI-
PQP85_RS24420 (PQP85_24420)107340..107615+276WP_001020576.1hypothetical protein-
PQP85_RS24425 (PQP85_24425)107615..108328+714WP_000801115.1hypothetical protein-
PQP85_RS24430 (PQP85_24430)108453..109037+585WP_001575501.1hypothetical protein-
PQP85_RS24435 (PQP85_24435)109110..109322+213WP_000063794.1FaeA/PapI family transcriptional regulator-
PQP85_RS24440 (PQP85_24440)109583..109744+162WP_001816720.1hypothetical protein-
PQP85_RS24445 (PQP85_24445)109770..110618+849WP_000175391.1SdiA-regulated domain-containing protein-
PQP85_RS24450 (PQP85_24450)111188..111616-429WP_000812999.1type II toxin-antitoxin system VapC family toxinToxin
PQP85_RS24455 (PQP85_24455)111613..111843-231WP_001261283.1type II toxin-antitoxin system VapB family antitoxinAntitoxin
PQP85_RS24460 (PQP85_24460)112588..112806+219WP_000813641.1type II toxin-antitoxin system antitoxin CcdA-
PQP85_RS24465 (PQP85_24465)112808..113113+306WP_001159863.1type II toxin-antitoxin system toxin CcdB-
PQP85_RS24470 (PQP85_24470)113115..113405+291WP_001266176.1hypothetical protein-
PQP85_RS24475 (PQP85_24475)113402..113923+522WP_000198608.1hypothetical protein-
PQP85_RS24480 (PQP85_24480)113958..114740+783WP_000082169.1site-specific integrase-
PQP85_RS24485 (PQP85_24485)114749..115432+684WP_001751692.1EAL domain-containing protein-
PQP85_RS24490 (PQP85_24490)115486..115974+489WP_001075507.1CaiF/GrlA family transcriptional regulator-
PQP85_RS24495 (PQP85_24495)115968..116304+337Protein_148hypothetical protein-
PQP85_RS24500 (PQP85_24500)116295..116636+342Protein_149LysM peptidoglycan-binding domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideConjugative plasmidblaTEM-1B / aph(3')-Ia / blaCMY-2 / sul2 / aph(3'')-Ib / aph(6)-Id / tet(A) / floRfaeH / faeI / fdeC / spvC / spvB1..178387178387


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-133)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15483.03 Da        Isoelectric Point: 7.6736

>T270692 WP_000812999.1 NZ_CP117347:c111616-111188 [Salmonella enterica subsp. enterica serovar Dublin]
MKQPRTKTYMLDTCICSFIMREQSEAVLKRLEQAVLRGHRIVISAITYSEMRFGATGPKASPRLVQLVDAFCARLDAILP
WDRAAVDATTEIKVALCLAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVS

Download         Length: 429 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8737.83 Da        Isoelectric Point: 4.3775

>AT270692 WP_001261283.1 NZ_CP117347:c111843-111613 [Salmonella enterica subsp. enterica serovar Dublin]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQLEKADPDFMAEREDVVSDEGRFEL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBM7RF18

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A6X6R7C5

References