Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4346522..4347303 Replicon chromosome
Accession NZ_CP117346
Organism Salmonella enterica subsp. enterica serovar Dublin strain RM104

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A0R9NZI3
Locus tag PQP85_RS21475 Protein ID WP_000625912.1
Coordinates 4346522..4347013 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID M7RNV8
Locus tag PQP85_RS21480 Protein ID WP_001110450.1
Coordinates 4347010..4347303 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP85_RS21440 (4341982) 4341982..4342329 + 348 WP_000887832.1 divalent cation tolerance protein CutA -
PQP85_RS21445 (4342305) 4342305..4344008 + 1704 WP_000068885.1 protein-disulfide reductase DsbD -
PQP85_RS21450 (4344045) 4344045..4344620 + 576 WP_001188509.1 transcriptional regulator -
PQP85_RS21460 (4344891) 4344891..4344965 - 75 Protein_4199 helix-turn-helix domain-containing protein -
PQP85_RS21465 (4345345) 4345345..4345422 + 78 Protein_4200 porin family protein -
PQP85_RS21470 (4345522) 4345522..4346274 + 753 WP_000842432.1 non-specific acid phosphatase -
PQP85_RS21475 (4346522) 4346522..4347013 - 492 WP_000625912.1 GNAT family N-acetyltransferase Toxin
PQP85_RS21480 (4347010) 4347010..4347303 - 294 WP_001110450.1 DUF1778 domain-containing protein Antitoxin
PQP85_RS21485 (4347620) 4347620..4347842 + 223 Protein_4204 hypothetical protein -
PQP85_RS21490 (4348106) 4348106..4348981 + 876 WP_000921679.1 AraC family transcriptional regulator -
PQP85_RS21495 (4348978) 4348978..4349265 + 288 WP_001269916.1 transcriptional regulator RtsB -
PQP85_RS21500 (4349288) 4349288..4349503 + 216 WP_001595136.1 hypothetical protein -
PQP85_RS21505 (4349511) 4349511..4349780 + 270 WP_077906657.1 hypothetical protein -
PQP85_RS21510 (4350074) 4350074..4350979 - 906 WP_001268195.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17606.43 Da        Isoelectric Point: 7.7297

>T270688 WP_000625912.1 NZ_CP117346:c4347013-4346522 [Salmonella enterica subsp. enterica serovar Dublin]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSSVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10949.56 Da        Isoelectric Point: 8.6141

>AT270688 WP_001110450.1 NZ_CP117346:c4347303-4347010 [Salmonella enterica subsp. enterica serovar Dublin]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NZI3

Antitoxin

Source ID Structure
AlphaFold DB A0A0R9PGG6

References