Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4239582..4240098 Replicon chromosome
Accession NZ_CP117346
Organism Salmonella enterica subsp. enterica serovar Dublin strain RM104

Toxin (Protein)


Gene name relE Uniprot ID M7RIY5
Locus tag PQP85_RS20900 Protein ID WP_000220574.1
Coordinates 4239582..4239866 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag PQP85_RS20905 Protein ID WP_000212724.1
Coordinates 4239856..4240098 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP85_RS20885 (4234698) 4234698..4236350 + 1653 WP_001751520.1 alpha,alpha-phosphotrehalase -
PQP85_RS20890 (4236759) 4236759..4238897 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
PQP85_RS20895 (4239114) 4239114..4239578 + 465 WP_001009173.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
PQP85_RS20900 (4239582) 4239582..4239866 - 285 WP_000220574.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PQP85_RS20905 (4239856) 4239856..4240098 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PQP85_RS20910 (4240176) 4240176..4242089 - 1914 WP_001212138.1 PRD domain-containing protein -
PQP85_RS20915 (4242106) 4242106..4242846 - 741 WP_000779259.1 KDGP aldolase family protein -
PQP85_RS20920 (4242843) 4242843..4243961 - 1119 WP_001139169.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
PQP85_RS20925 (4243945) 4243945..4245078 - 1134 WP_000459958.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10869.68 Da        Isoelectric Point: 9.8739

>T270687 WP_000220574.1 NZ_CP117346:c4239866-4239582 [Salmonella enterica subsp. enterica serovar Dublin]
MTYELEFDPRALKEWHKLGDTVKAQIKKKLADVLLDPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT270687 WP_000212724.1 NZ_CP117346:c4240098-4239856 [Salmonella enterica subsp. enterica serovar Dublin]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M7RIY5

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References