Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4343564..4344345 Replicon chromosome
Accession NZ_CP117343
Organism Salmonella enterica subsp. enterica serovar Dublin strain RM105

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A0R9NZI3
Locus tag PQP76_RS21445 Protein ID WP_000625912.1
Coordinates 4343564..4344055 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID M7RNV8
Locus tag PQP76_RS21450 Protein ID WP_001110450.1
Coordinates 4344052..4344345 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP76_RS21410 (4339024) 4339024..4339371 + 348 WP_000887832.1 divalent cation tolerance protein CutA -
PQP76_RS21415 (4339347) 4339347..4341050 + 1704 WP_000068885.1 protein-disulfide reductase DsbD -
PQP76_RS21420 (4341087) 4341087..4341662 + 576 WP_001188509.1 transcriptional regulator -
PQP76_RS21430 (4341933) 4341933..4342007 - 75 Protein_4195 helix-turn-helix domain-containing protein -
PQP76_RS21435 (4342387) 4342387..4342464 + 78 Protein_4196 porin family protein -
PQP76_RS21440 (4342564) 4342564..4343316 + 753 WP_000842432.1 non-specific acid phosphatase -
PQP76_RS21445 (4343564) 4343564..4344055 - 492 WP_000625912.1 GNAT family N-acetyltransferase Toxin
PQP76_RS21450 (4344052) 4344052..4344345 - 294 WP_001110450.1 DUF1778 domain-containing protein Antitoxin
PQP76_RS21455 (4344662) 4344662..4344884 + 223 Protein_4200 hypothetical protein -
PQP76_RS21460 (4345148) 4345148..4346023 + 876 WP_000921679.1 AraC family transcriptional regulator -
PQP76_RS21465 (4346020) 4346020..4346307 + 288 WP_001269916.1 transcriptional regulator RtsB -
PQP76_RS21470 (4346330) 4346330..4346545 + 216 WP_001595136.1 hypothetical protein -
PQP76_RS21475 (4346553) 4346553..4346822 + 270 WP_077906657.1 hypothetical protein -
PQP76_RS21480 (4347116) 4347116..4348021 - 906 WP_001268195.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17606.43 Da        Isoelectric Point: 7.7297

>T270665 WP_000625912.1 NZ_CP117343:c4344055-4343564 [Salmonella enterica subsp. enterica serovar Dublin]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSSVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10949.56 Da        Isoelectric Point: 8.6141

>AT270665 WP_001110450.1 NZ_CP117343:c4344345-4344052 [Salmonella enterica subsp. enterica serovar Dublin]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NZI3

Antitoxin

Source ID Structure
AlphaFold DB A0A0R9PGG6

References