Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4236624..4237140 Replicon chromosome
Accession NZ_CP117343
Organism Salmonella enterica subsp. enterica serovar Dublin strain RM105

Toxin (Protein)


Gene name relE Uniprot ID M7RIY5
Locus tag PQP76_RS20870 Protein ID WP_000220574.1
Coordinates 4236624..4236908 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag PQP76_RS20875 Protein ID WP_000212724.1
Coordinates 4236898..4237140 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP76_RS20855 (4231740) 4231740..4233392 + 1653 WP_001751520.1 alpha,alpha-phosphotrehalase -
PQP76_RS20860 (4233801) 4233801..4235939 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
PQP76_RS20865 (4236156) 4236156..4236620 + 465 WP_001009173.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
PQP76_RS20870 (4236624) 4236624..4236908 - 285 WP_000220574.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PQP76_RS20875 (4236898) 4236898..4237140 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PQP76_RS20880 (4237218) 4237218..4239131 - 1914 WP_001212138.1 PRD domain-containing protein -
PQP76_RS20885 (4239148) 4239148..4239888 - 741 WP_000779259.1 KDGP aldolase family protein -
PQP76_RS20890 (4239885) 4239885..4241003 - 1119 WP_001139169.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
PQP76_RS20895 (4240987) 4240987..4242120 - 1134 WP_000459958.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10869.68 Da        Isoelectric Point: 9.8739

>T270664 WP_000220574.1 NZ_CP117343:c4236908-4236624 [Salmonella enterica subsp. enterica serovar Dublin]
MTYELEFDPRALKEWHKLGDTVKAQIKKKLADVLLDPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT270664 WP_000212724.1 NZ_CP117343:c4237140-4236898 [Salmonella enterica subsp. enterica serovar Dublin]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M7RIY5

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References