Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3545212..3545832 Replicon chromosome
Accession NZ_CP117343
Organism Salmonella enterica subsp. enterica serovar Dublin strain RM105

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PQP76_RS17665 Protein ID WP_001280991.1
Coordinates 3545614..3545832 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag PQP76_RS17660 Protein ID WP_000344807.1
Coordinates 3545212..3545586 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP76_RS17650 (3540351) 3540351..3541544 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PQP76_RS17655 (3541567) 3541567..3544716 + 3150 WP_052897443.1 efflux RND transporter permease AcrB -
PQP76_RS17660 (3545212) 3545212..3545586 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
PQP76_RS17665 (3545614) 3545614..3545832 + 219 WP_001280991.1 HHA domain-containing protein Toxin
PQP76_RS17670 (3546011) 3546011..3546562 + 552 WP_001278787.1 maltose O-acetyltransferase -
PQP76_RS17675 (3546680) 3546680..3547150 + 471 WP_000136183.1 YlaC family protein -
PQP76_RS17680 (3547206) 3547206..3547346 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
PQP76_RS17685 (3547352) 3547352..3547612 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
PQP76_RS17690 (3547837) 3547837..3549387 + 1551 WP_000213140.1 EAL domain-containing protein -
PQP76_RS17700 (3549618) 3549618..3550007 + 390 WP_000961287.1 MGMT family protein -
PQP76_RS17705 (3550040) 3550040..3550609 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T270659 WP_001280991.1 NZ_CP117343:3545614-3545832 [Salmonella enterica subsp. enterica serovar Dublin]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT270659 WP_000344807.1 NZ_CP117343:3545212-3545586 [Salmonella enterica subsp. enterica serovar Dublin]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References