Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 824280..824940 Replicon chromosome
Accession NZ_CP117343
Organism Salmonella enterica subsp. enterica serovar Dublin strain RM105

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag PQP76_RS03975 Protein ID WP_000244756.1
Coordinates 824527..824940 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag PQP76_RS03970 Protein ID WP_000351186.1
Coordinates 824280..824546 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP76_RS03950 (820211) 820211..821644 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
PQP76_RS03955 (821799) 821799..822113 + 315 WP_001182980.1 N(4)-acetylcytidine aminohydrolase -
PQP76_RS03960 (822275) 822275..822934 + 660 WP_000250289.1 hemolysin III family protein -
PQP76_RS03965 (823050) 823050..824030 - 981 WP_000874174.1 tRNA-modifying protein YgfZ -
PQP76_RS03970 (824280) 824280..824546 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
PQP76_RS03975 (824527) 824527..824940 + 414 WP_000244756.1 protein YgfX Toxin
PQP76_RS03980 (824993) 824993..825514 - 522 WP_001055885.1 flavodoxin FldB -
PQP76_RS03985 (825627) 825627..826523 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
PQP76_RS03990 (826547) 826547..827260 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PQP76_RS03995 (827266) 827266..828999 + 1734 WP_000813387.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T270652 WP_000244756.1 NZ_CP117343:824527-824940 [Salmonella enterica subsp. enterica serovar Dublin]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT270652 WP_000351186.1 NZ_CP117343:824280-824546 [Salmonella enterica subsp. enterica serovar Dublin]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References