Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 199771..200531 Replicon chromosome
Accession NZ_CP117343
Organism Salmonella enterica subsp. enterica serovar Dublin strain RM105

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag PQP76_RS00935 Protein ID WP_000533909.1
Coordinates 200046..200531 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag PQP76_RS00930 Protein ID WP_000965886.1
Coordinates 199771..200058 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQP76_RS00910 (195176) 195176..196087 + 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
PQP76_RS00915 (196097) 196097..198166 + 2070 WP_001291741.1 glycine--tRNA ligase subunit beta -
PQP76_RS00920 (198556) 198556..198909 + 354 Protein_182 IS3 family transposase -
PQP76_RS00925 (199126) 199126..199593 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
PQP76_RS00930 (199771) 199771..200058 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
PQP76_RS00935 (200046) 200046..200531 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
PQP76_RS00940 (200902) 200902..201441 - 540 WP_000047147.1 copper-binding periplasmic metallochaperone CueP -
PQP76_RS00945 (201615) 201615..201827 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
PQP76_RS00950 (202115) 202115..202405 - 291 WP_000455790.1 HTH-type transcriptional regulator -
PQP76_RS00955 (202844) 202844..203554 + 711 WP_000190524.1 DUF3053 domain-containing protein -
PQP76_RS00960 (203604) 203604..204578 - 975 WP_000804678.1 glyoxylate/hydroxypyruvate reductase GhrB -
PQP76_RS00965 (204797) 204797..205459 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T270649 WP_000533909.1 NZ_CP117343:200046-200531 [Salmonella enterica subsp. enterica serovar Dublin]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT270649 WP_000965886.1 NZ_CP117343:199771-200058 [Salmonella enterica subsp. enterica serovar Dublin]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References