Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 13102..13627 Replicon plasmid pRM111_2
Accession NZ_CP117342
Organism Salmonella enterica subsp. enterica serovar Dublin strain RM111

Toxin (Protein)


Gene name ccdB Uniprot ID I3W3D5
Locus tag PQQ02_RS24345 Protein ID WP_001159863.1
Coordinates 13322..13627 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7S5D0
Locus tag PQQ02_RS24340 Protein ID WP_000813641.1
Coordinates 13102..13320 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ02_RS24305 (PQQ02_24305) 8129..8842 + 714 WP_000801115.1 hypothetical protein -
PQQ02_RS24310 (PQQ02_24310) 8967..9551 + 585 WP_001575501.1 hypothetical protein -
PQQ02_RS24315 (PQQ02_24315) 9624..9836 + 213 WP_000063794.1 FaeA/PapI family transcriptional regulator -
PQQ02_RS24320 (PQQ02_24320) 10097..10258 + 162 WP_001816720.1 hypothetical protein -
PQQ02_RS24325 (PQQ02_24325) 10284..11132 + 849 WP_000175391.1 SdiA-regulated domain-containing protein -
PQQ02_RS24330 (PQQ02_24330) 11702..12130 - 429 WP_000812999.1 type II toxin-antitoxin system VapC family toxin -
PQQ02_RS24335 (PQQ02_24335) 12127..12357 - 231 WP_001261283.1 type II toxin-antitoxin system VapB family antitoxin -
PQQ02_RS24340 (PQQ02_24340) 13102..13320 + 219 WP_000813641.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
PQQ02_RS24345 (PQQ02_24345) 13322..13627 + 306 WP_001159863.1 type II toxin-antitoxin system toxin CcdB Toxin
PQQ02_RS24350 (PQQ02_24350) 13629..13919 + 291 WP_001266176.1 hypothetical protein -
PQQ02_RS24355 (PQQ02_24355) 13916..14437 + 522 WP_000198608.1 hypothetical protein -
PQQ02_RS24360 (PQQ02_24360) 14472..15254 + 783 WP_000082169.1 site-specific integrase -
PQQ02_RS24365 (PQQ02_24365) 15263..15946 + 684 WP_001751692.1 EAL domain-containing protein -
PQQ02_RS24370 (PQQ02_24370) 16000..16488 + 489 WP_001075507.1 CaiF/GrlA family transcriptional regulator -
PQQ02_RS24375 (PQQ02_24375) 16482..16818 + 337 Protein_24 hypothetical protein -
PQQ02_RS24380 (PQQ02_24380) 16809..17150 + 342 Protein_25 LysM peptidoglycan-binding domain-containing protein -
PQQ02_RS24385 (PQQ02_24385) 17045..17590 + 546 WP_071591236.1 inverse autotransporter beta domain-containing protein -
PQQ02_RS24390 (PQQ02_24390) 17657..18016 - 360 WP_001675600.1 helix-turn-helix domain-containing protein -
PQQ02_RS24395 (PQQ02_24395) 18073..18498 + 426 WP_000064919.1 IS200/IS605 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - faeH / faeI / spvC / spvB 1..75130 75130


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11587.48 Da        Isoelectric Point: 6.9787

>T270647 WP_001159863.1 NZ_CP117342:13322-13627 [Salmonella enterica subsp. enterica serovar Dublin]
MQFKVYTCKRESRYRLFVDVQSDIIDTPGRRMAVPLVSARLLSEKVPRDLYPVMHIGDEPYRLLTTDMTSVPATVIGEEV
ADLSLRENDIKNAINLMFRGI

Download         Length: 306 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8314.16 Da        Isoelectric Point: 4.5203

>AT270647 WP_000813641.1 NZ_CP117342:13102-13320 [Salmonella enterica subsp. enterica serovar Dublin]
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWQEENREGMAEVASFIEANGSFADDNRNW

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I3W3D5

Antitoxin

Source ID Structure
AlphaFold DB A0A656ICA6

References