Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 11702..12357 Replicon plasmid pRM111_2
Accession NZ_CP117342
Organism Salmonella enterica subsp. enterica serovar Dublin strain RM111

Toxin (Protein)


Gene name vagD Uniprot ID M7RF18
Locus tag PQQ02_RS24330 Protein ID WP_000812999.1
Coordinates 11702..12130 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID H9AC95
Locus tag PQQ02_RS24335 Protein ID WP_001261283.1
Coordinates 12127..12357 (-) Length 77 a.a.

Genomic Context

PQQ02_RS24295PQQ02_RS24300PQQ02_RS24305PQQ02_RS24310PQQ02_RS24315PQQ02_RS24320PQQ02_RS24325PQQ02_RS24340PQQ02_RS24345PQQ02_RS24350PQQ02_RS24355PQQ02_RS24360PQQ02_RS24365PQQ02_RS24370PQQ02_RS24375PQQ02_RS24380PQQ02_RS24330PQQ02_RS24335
Location: 7103..7867 (765 bp)
Type: Others
Protein ID: WP_000827659.1
Location: 7854..8129 (276 bp)
Type: Others
Protein ID: WP_001020576.1
Location: 8129..8842 (714 bp)
Type: Others
Protein ID: WP_000801115.1
Location: 8967..9551 (585 bp)
Type: Others
Protein ID: WP_001575501.1
Location: 9624..9836 (213 bp)
Type: Others
Protein ID: WP_000063794.1
Location: 10097..10258 (162 bp)
Type: Others
Protein ID: WP_001816720.1
Location: 10284..11132 (849 bp)
Type: Others
Protein ID: WP_000175391.1
Location: 13102..13320 (219 bp)
Type: Others
Protein ID: WP_000813641.1
Location: 13322..13627 (306 bp)
Type: Others
Protein ID: WP_001159863.1
Location: 13629..13919 (291 bp)
Type: Others
Protein ID: WP_001266176.1
Location: 13916..14437 (522 bp)
Type: Others
Protein ID: WP_000198608.1
Location: 14472..15254 (783 bp)
Type: Others
Protein ID: WP_000082169.1
Location: 15263..15946 (684 bp)
Type: Others
Protein ID: WP_001751692.1
Location: 16000..16488 (489 bp)
Type: Others
Protein ID: WP_001075507.1
Location: 16482..16818 (337 bp)
Type: Others
Protein ID: Protein_24
Location: 16809..17150 (342 bp)
Type: Others
Protein ID: Protein_25
Location: 11702..12130 (429 bp)
Type: Toxin
Protein ID: WP_000812999.1
Location: 12127..12357 (231 bp)
Type: Antitoxin
Protein ID: WP_001261283.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
PQQ02_RS24295 (PQQ02_24295)7103..7867+765WP_000827659.1K88 minor fimbrial subunit faeI-
PQQ02_RS24300 (PQQ02_24300)7854..8129+276WP_001020576.1hypothetical protein-
PQQ02_RS24305 (PQQ02_24305)8129..8842+714WP_000801115.1hypothetical protein-
PQQ02_RS24310 (PQQ02_24310)8967..9551+585WP_001575501.1hypothetical protein-
PQQ02_RS24315 (PQQ02_24315)9624..9836+213WP_000063794.1FaeA/PapI family transcriptional regulator-
PQQ02_RS24320 (PQQ02_24320)10097..10258+162WP_001816720.1hypothetical protein-
PQQ02_RS24325 (PQQ02_24325)10284..11132+849WP_000175391.1SdiA-regulated domain-containing protein-
PQQ02_RS24330 (PQQ02_24330)11702..12130-429WP_000812999.1type II toxin-antitoxin system VapC family toxinToxin
PQQ02_RS24335 (PQQ02_24335)12127..12357-231WP_001261283.1type II toxin-antitoxin system VapB family antitoxinAntitoxin
PQQ02_RS24340 (PQQ02_24340)13102..13320+219WP_000813641.1type II toxin-antitoxin system antitoxin CcdA-
PQQ02_RS24345 (PQQ02_24345)13322..13627+306WP_001159863.1type II toxin-antitoxin system toxin CcdB-
PQQ02_RS24350 (PQQ02_24350)13629..13919+291WP_001266176.1hypothetical protein-
PQQ02_RS24355 (PQQ02_24355)13916..14437+522WP_000198608.1hypothetical protein-
PQQ02_RS24360 (PQQ02_24360)14472..15254+783WP_000082169.1site-specific integrase-
PQQ02_RS24365 (PQQ02_24365)15263..15946+684WP_001751692.1EAL domain-containing protein-
PQQ02_RS24370 (PQQ02_24370)16000..16488+489WP_001075507.1CaiF/GrlA family transcriptional regulator-
PQQ02_RS24375 (PQQ02_24375)16482..16818+337Protein_24hypothetical protein-
PQQ02_RS24380 (PQQ02_24380)16809..17150+342Protein_25LysM peptidoglycan-binding domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid-faeH / faeI / spvC / spvB1..7513075130


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-133)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15483.03 Da        Isoelectric Point: 7.6736

>T270646 WP_000812999.1 NZ_CP117342:c12130-11702 [Salmonella enterica subsp. enterica serovar Dublin]
MKQPRTKTYMLDTCICSFIMREQSEAVLKRLEQAVLRGHRIVISAITYSEMRFGATGPKASPRLVQLVDAFCARLDAILP
WDRAAVDATTEIKVALCLAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVS

Download         Length: 429 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8737.83 Da        Isoelectric Point: 4.3775

>AT270646 WP_001261283.1 NZ_CP117342:c12357-12127 [Salmonella enterica subsp. enterica serovar Dublin]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQLEKADPDFMAEREDVVSDEGRFEL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBM7RF18

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A6X6R7C5

References