270642

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4341355..4342136 Replicon chromosome
Accession NZ_CP117340
Organism Salmonella enterica subsp. enterica serovar Dublin strain RM111

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A0R9NZI3
Locus tag PQQ02_RS21430 Protein ID WP_000625912.1
Coordinates 4341355..4341846 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID M7RNV8
Locus tag PQQ02_RS21435 Protein ID WP_001110450.1
Coordinates 4341843..4342136 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ02_RS21395 (4336815) 4336815..4337162 + 348 WP_000887832.1 divalent cation tolerance protein CutA -
PQQ02_RS21400 (4337138) 4337138..4338841 + 1704 WP_000068885.1 protein-disulfide reductase DsbD -
PQQ02_RS21405 (4338878) 4338878..4339453 + 576 WP_001188509.1 transcriptional regulator -
PQQ02_RS21415 (4339724) 4339724..4339798 - 75 Protein_4190 helix-turn-helix domain-containing protein -
PQQ02_RS21420 (4340178) 4340178..4340255 + 78 Protein_4191 porin family protein -
PQQ02_RS21425 (4340355) 4340355..4341107 + 753 WP_000842432.1 non-specific acid phosphatase -
PQQ02_RS21430 (4341355) 4341355..4341846 - 492 WP_000625912.1 GNAT family N-acetyltransferase Toxin
PQQ02_RS21435 (4341843) 4341843..4342136 - 294 WP_001110450.1 DUF1778 domain-containing protein Antitoxin
PQQ02_RS21440 (4342453) 4342453..4342675 + 223 Protein_4195 hypothetical protein -
PQQ02_RS21445 (4342939) 4342939..4343813 + 875 Protein_4196 AraC family transcriptional regulator -
PQQ02_RS21450 (4343810) 4343810..4344097 + 288 WP_001269916.1 transcriptional regulator RtsB -
PQQ02_RS21455 (4344120) 4344120..4344335 + 216 WP_001595136.1 hypothetical protein -
PQQ02_RS21460 (4344343) 4344343..4344612 + 270 WP_077906657.1 hypothetical protein -
PQQ02_RS21465 (4344906) 4344906..4345811 - 906 WP_001268195.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17606.43 Da        Isoelectric Point: 7.7297

>T270642 WP_000625912.1 NZ_CP117340:c4341846-4341355 [Salmonella enterica subsp. enterica serovar Dublin]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSSVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10949.56 Da        Isoelectric Point: 8.6141

>AT270642 WP_001110450.1 NZ_CP117340:c4342136-4341843 [Salmonella enterica subsp. enterica serovar Dublin]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NZI3

Antitoxin

Source ID Structure
AlphaFold DB A0A0R9PGG6

References