Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4234420..4234936 Replicon chromosome
Accession NZ_CP117340
Organism Salmonella enterica subsp. enterica serovar Dublin strain RM111

Toxin (Protein)


Gene name relE Uniprot ID M7RIY5
Locus tag PQQ02_RS20855 Protein ID WP_000220574.1
Coordinates 4234420..4234704 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag PQQ02_RS20860 Protein ID WP_000212724.1
Coordinates 4234694..4234936 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PQQ02_RS20840 (4229536) 4229536..4231188 + 1653 WP_001751520.1 alpha,alpha-phosphotrehalase -
PQQ02_RS20845 (4231597) 4231597..4233735 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
PQQ02_RS20850 (4233952) 4233952..4234416 + 465 WP_001009173.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
PQQ02_RS20855 (4234420) 4234420..4234704 - 285 WP_000220574.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PQQ02_RS20860 (4234694) 4234694..4234936 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PQQ02_RS20865 (4235014) 4235014..4236927 - 1914 WP_001212138.1 PRD domain-containing protein -
PQQ02_RS20870 (4236944) 4236944..4237684 - 741 WP_000779259.1 KDGP aldolase family protein -
PQQ02_RS20875 (4237681) 4237681..4238799 - 1119 WP_001139169.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
PQQ02_RS20880 (4238783) 4238783..4239916 - 1134 WP_000459958.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10869.68 Da        Isoelectric Point: 9.8739

>T270641 WP_000220574.1 NZ_CP117340:c4234704-4234420 [Salmonella enterica subsp. enterica serovar Dublin]
MTYELEFDPRALKEWHKLGDTVKAQIKKKLADVLLDPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT270641 WP_000212724.1 NZ_CP117340:c4234936-4234694 [Salmonella enterica subsp. enterica serovar Dublin]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M7RIY5

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References